Brain, CSF, and tumor pharmacokinetics of ?-difluoromethylornithine in rats and dogs
| Autor: | Judit Csejtey, Victor A. Levin, Deborah Byrd |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Ornithine
Cancer Research Pathology medicine.medical_specialty Eflornithine Brain tumor Antineoplastic Agents Toxicology Beagle Alpha-Difluoromethylornithine Dogs Cerebrospinal fluid Pharmacokinetics medicine Extracellular Animals Tissue Distribution Pharmacology (medical) Cerebrospinal Fluid Pharmacology Brain Neoplasms business.industry Brain Neoplasms Experimental Rat brain medicine.disease Rats Inbred F344 Rats Kinetics Oncology business Neoplasm Transplantation medicine.drug |
| Zdroj: | Cancer Chemotherapy and Pharmacology. 10 |
| ISSN: | 1432-0843 0344-5704 |
| DOI: | 10.1007/bf00255762 |
| Popis: | We have determined the pharmacokinetic parameters for diffusion of alpha-[5-14C]-difluoromethylornithine (DFMO) from blood to brain, blood to cerebrospinal fluid (CSF), 9L rat brain tumor to adjacent brain, and blood to the subcutaneously-implanted 9L tumor in rats, and within the CSF of beagle dogs. DFMO diffusion across the blood-brain and blood-CSF barriers is quite restricted in both rats and dogs, but diffusion across the defective capillary system of both subcutaneous and intracerebral 9L tumors in rats is not. Under steady-state plasma conditions in rats, uptake of DFMO by the intracerebral 9L tumor and diffusion from tumor 5-6 mm into adjacent brain is not restricted; tissue/plasma ratios were approximately 1. Therapeutic efficacy will therefore not be limited by transport of DFMO into tumor or to the extracellular environment of tumor. |
| Databáze: | OpenAIRE |
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