The indigenous South American Tsimane exhibit relatively modest decrease in brain volume with age despite high systemic inflammation
| Autor: | Margaret Gatz, Andrei Irimia, Maria Calvillo, Caleb E. Finch, Hillard Kaplan, Adel H. Allam, David J. Robles, Edmond Seabright, Angela R. Garcia, James D. Sutherland, L. Samuel Wann, Wendy J. Mack, Benjamin C. Trumble, Van Anh Ngo, Sarah Alami, Gregory S. Thomas, E. Meng Law, Nahian F. Chowdhury, Randall C. Thompson, Chris J. Rowan, Alexander S. Maher, Kenneth A. Rostowsky, Paul L. Hooper, Daniel K. Cummings, Michael Gurven, M. Linda Sutherland, David E. Michalik, Nikhil N. Chaudhari, Jonathan Stieglitz |
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| Přispěvatelé: | Le Couteur, David |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine THE JOURNAL OF GERONTOLOGY: Biological Sciences Aging Coronary Artery Disease Disease Cardiovascular Systemic inflammation 0302 clinical medicine 80 and over B- ECONOMIE ET FINANCE Aged 80 and over education.field_of_study Brain Organ Size Middle Aged Cardiovascular disease Heart Disease Infectious Diseases Brain size Cohort Biomedical Imaging Female medicine.symptom Adult Bolivia Clinical Sciences Population 03 medical and health sciences Atrophy medicine Humans Dementia Neurodegeneration Indigenous Peoples education Life Style Aged Inflammation Cerebral atrophy business.industry Neurosciences South America Atherosclerosis medicine.disease Brain Disorders Good Health and Well Being 030104 developmental biology Brain aging Geriatrics and Gerontology business Gerontology 030217 neurology & neurosurgery Demography |
| Zdroj: | J Gerontol A Biol Sci Med Sci The journals of gerontology. Series A, Biological sciences and medical sciences, vol 76, iss 12 |
| Popis: | Brain atrophy is correlated with risk of cognitive impairment, functional decline, and dementia. Despite a high infectious disease burden, Tsimane forager-horticulturists of Bolivia have the lowest prevalence of coronary atherosclerosis of any studied population and present few cardiovascular disease (CVD) risk factors despite a high burden of infections and therefore inflammation. This study (a) examines the statistical association between brain volume (BV) and age for Tsimane and (b) compares this association to that of 3 industrialized populations in the United States and Europe. This cohort-based panel study enrolled 746 participants aged 40–94 (396 males), from whom computed tomography (CT) head scans were acquired. BV and intracranial volume (ICV) were calculated from automatic head CT segmentations. The linear regression coefficient estimate β^T of the Tsimane (T), describing the relationship between age (predictor) and BV (response, as a percentage of ICV), was calculated for the pooled sample (including both sexes) and for each sex. β^T was compared to the corresponding regression coefficient estimate β^R of samples from the industrialized reference (R) countries. For all comparisons, the null hypothesis β T = β R was rejected both for the combined samples of males and females, as well as separately for each sex. Our results indicate that the Tsimane exhibit a significantly slower decrease in BV with age than populations in the United States and Europe. Such reduced rates of BV decrease, together with a subsistence lifestyle and low CVD risk, may protect brain health despite considerable chronic inflammation related to infectious burden. |
| Databáze: | OpenAIRE |
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