Iontophoresis and electroporation: comparisons and contrasts
| Autor: | Ajay K. Banga, Tapash K. Ghosh, Sagarika Bose |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Drug
Iontophoresis business.industry Administration Topical media_common.quotation_subject Electroporation Pharmaceutical Science Pharmacology Administration Cutaneous Pharmaceutical Preparations Pharmaceutical technology Drug delivery Animals Humans Medicine Delivery system business Biomedical engineering Transdermal media_common |
| Zdroj: | International Journal of Pharmaceutics. 179:1-19 |
| ISSN: | 0378-5173 |
| DOI: | 10.1016/s0378-5173(98)00360-3 |
| Popis: | The techniques of iontophoresis and electroporation can be used to enhance topical and transdermal drug delivery. Iontophoresis applies a small low voltage (typically 10 V or less) continuous constant current (typically 0.5 mA/cm2 or less) to push a charged drug into skin or other tissue. In contrast, electroporation applies a high voltage (typically, ?100 V) pulse for a very short (micros-ms) duration to permeabilize the skin. This electric assistance of drug delivery across skin will expand the scope of transdermal delivery to hydrophilic macromolecules such as the drugs of biotechnology. These two techniques differ in several aspects such as the mode of application and pathways of transport but can be used together for effective drug delivery. Iontophoresis is already used clinically in physical therapy clinics and is close to commercialization for development of a systemic delivery patch with miniaturized circuits and similar in overall size to a passive patch. The use of electroporation for drug delivery is relatively new and is being actively researched. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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