Combination of genetic variants in cyclin D1 and retinoblastoma genes predict clinical outcome in oral cancer patients
| Autor: | Abitha Murali, Bipin T. Varghese, R. Rejnish Kumar, S. Kannan |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Oncology Male medicine.medical_specialty Genotype Single-nucleotide polymorphism Kaplan-Meier Estimate Biology Bioinformatics Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Cyclin D1 Gene Frequency Predictive Value of Tests Internal medicine medicine Biomarkers Tumor SNP Humans Genes Retinoblastoma Aged Mouth neoplasm Retinoblastoma Cancer General Medicine Cell cycle Middle Aged medicine.disease Prognosis 030104 developmental biology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Mouth Neoplasms |
| Zdroj: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 37(3) |
| ISSN: | 1423-0380 |
| Popis: | Oral cancer is a dreadful disease with a wide variation in geographical distribution. In order to identify some useful biomarkers for the disease prognosis, the present study assessed the influence of single nucleotide polymorphisms (SNPs) in cell cycle genes on survival in a well-annotated set of patients with oral squamous cell carcinoma (OSCC). The study examined 12 sequence variants or SNPs in selected cell cycle genes, with prognostic outcomes in 311 oral cancer patients. Our analysis showed that SNPs in cyclin D1:rs9344 and retinoblastoma:rs427686 genes showed a strong correlation with disease-free survival. In addition, the cumulative effect of these SNPs significantly and independently predicts the survival. Thus, the current study identified genotypes (SNP signature), which can be used as novel prognostic biomarkers to stratify patients based on disease-free survival and therefore maybe helpful in therapeutic decision-making. |
| Databáze: | OpenAIRE |
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