Extracellular Vesicles and Bone-Associated Cancer
| Autor: | Jinlu Dai, Evan T. Keller, Alison B. Shupp, Karen M. Bussard |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Stromal cell Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Bone Neoplasms Cell Communication Exosome Article Bone remodeling 03 medical and health sciences Extracellular Vesicles 0302 clinical medicine medicine Tumor Microenvironment Humans Tumor microenvironment Chemistry Bone metastasis medicine.disease Microvesicles Crosstalk (biology) 030104 developmental biology Tumor progression Cancer research Disease Progression Signal Transduction |
| Zdroj: | Curr Osteoporos Rep |
| ISSN: | 1544-2241 |
| Popis: | PURPOSE OF REVIEW: In this review, we describe the biology of extracellular vesicles (EV) and how they contribute to bone-associated cancers. RECENT FINDINGS: Crosstalk between tumor and bone have been demonstrated to promote tumor and metastatic progression. In addition to direct cell to cell contact and soluble factors, such as cytokines, EVs mediate crosstalk between tumor and bone. EVs are composed of a heterogenous group of membrane-delineated vesicles of varying size range, mechanisms of formation and content. These include apoptotic bodies, microvesicles, large oncosomes and exosomes. EVs derived from primary tumors have been shown to alter bone remodeling and create formation of a pre-metastatic niche that favors development of bone metastasis. Similarly, EVs from marrow stromal cells have been shown to promote tumor progression. Additionally, EVs can act as therapeutic delivery vehicles due to their low immunogenicity and targeting specificity. SUMMARY: EVs play critical roles in intercellular communication. Multiple classes of EVs exist based on size on mechanism of formation. In addition to a role in pathophysiology, EVs can be exploited as therapeutic delivery vehicles. |
| Databáze: | OpenAIRE |
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