Components of the Vid30c are needed for the rapamycin-induced degradation of the high-affinity hexose transporter Hxt7p in Saccharomyces cerevisiae
| Autor: | George van der Merwe, Chris Snowdon, Chris Hlynialuk |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Saccharomyces cerevisiae Proteins
Monosaccharide Transport Proteins Nitrogen Saccharomyces cerevisiae Cell Vesicular Transport Proteins Biology Applied Microbiology and Biotechnology Microbiology Transcription (biology) medicine Gene family Sirolimus Gene Expression Profiling Protein turnover General Medicine biology.organism_classification Adaptation Physiological Hedgehog signaling pathway Gene expression profiling Mutagenesis Insertional medicine.anatomical_structure Glucose Biochemistry Microscopy Fluorescence Intracellular Gene Deletion |
| Zdroj: | FEMS yeast research. 8(2) |
| ISSN: | 1567-1356 |
| Popis: | Saccharomyces cerevisiae adapts to changing nutrient conditions by regulating its genome-wide transcription profile and cell-wide protein complement in correlation with the reigning nutrient conditions. The target of rapamycin (TOR) signalling pathway is one of the major control mechanisms within the cell that facilitates these changes. The transcription, intracellular trafficking, and protein turnover of nutrient transporters, including the hexose transporter proteins (Hxts), are regulated in response to nutrient conditions. The Vid and Gid proteins facilitate the nutrient-dependent degradation of the gluconeogenic enzymes FBPase and Mdh2p when glucose-starved cells are replenished with glucose. Three members of the VID and GID gene families, VID30/GID1, GID2, and VID28/GID5 are needed for the rapamycin or nitrogen starvation-induced degradation of the high-affinity hexose transporter Hxt7p is shown here. In addition, evidence that the functions of several Vid and Gid proteins are in close relation to the TOR signalling pathway is provided. |
| Databáze: | OpenAIRE |
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