Enantioselective addition of sodium bisulfite to nitroalkenes. A convenient approach to chiral sulfonic acids

Autor:	Amparo Sanz-Marco, Carlos Vila, M. Carmen Muñoz, Narjes Rezaei, Alvaro Castilla, Ehsan Sheikhi, José R. Pedro, Gonzalo Blay
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Catàlisi Sodium bisulfite Organocatalysis Organic Chemistry Enantioselective synthesis Organic chemistry Physical and Theoretical Chemistry Sulfonic acid Química orgànica
Zdroj:	Sheikhi, Ehsan Rezaei, Narjes Castilla, Alvaro Sanz Marco, Amparo Vila Descals, Carlos Muñoz, M. Carmen Pedro, José Ramón Blay Llinares, Gonzalo 2021 Enantioselective addition of sodium bisulfite to nitroalkenes. A convenient approach to chiral sulfonic acids European Journal of Organic Chemistry 2021 37 5284 5287 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname
Popis:	An enantioselective organocatalytic addition of sodium bisulfite to (E)-nitroalkenes has been developed by using a chiral bifunctional organocatalyst. The present methodology provides a variety of chiral β-nitroethanesulfonic acid compounds (17 examples) with excellent results: up to 99% yield and excellent enantioselectivity (up to 96% ee). The reaction tolerates (hetero)aryl and alkyl substituents on the β-nitroalkenes, and β,β-disubstituted nitroalkenes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db3e118597e5045515a5e911167f7ca https://hdl.handle.net/10550/80414 Zobrazit plný text záznamu