Recurrence of Ewing sarcoma: Is detection by imaging follow-up protocol associated with survival advantage?
| Autor: | Justus Kreyer, Stefan S. Bielack, Hans Gelderblom, Sebastian Bauer, Michael Schäfers, Matthias Weckesser, Thorsten Simon, Lars Stegger, Volker Vieth, Henk van den Berg, Melina Heinemann, Thomas Kühne, Wolf A Hassenpflug, Uta Dirksen, Herbert Jürgens, Andreas Ranft, Regina Mayer-Steinacker, Thorsten Langer, Selim Corbacioglu |
|---|---|
| Přispěvatelé: | Paediatric Oncology, CCA - Imaging and biomarkers |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Oncology Medizin Multimodal Imaging 030218 nuclear medicine & medical imaging 0302 clinical medicine Image Processing Computer-Assisted follow-up Longitudinal Studies Prospective Studies Young adult Child Prospective cohort study Hematology imaging Middle Aged Prognosis Combined Modality Therapy Survival Rate Child Preschool 030220 oncology & carcinogenesis Disease Progression Population study Female Sarcoma Adult medicine.medical_specialty recurrence Adolescent Bone Neoplasms Sarcoma Ewing survival Young Adult 03 medical and health sciences Internal medicine medicine Humans Survival rate Retrospective Studies business.industry Infant Retrospective cohort study medicine.disease Pediatrics Perinatology and Child Health Neoplasm Recurrence Local business Ewing sarcoma Follow-Up Studies |
| Zdroj: | Pediatric Blood & Cancer, 65(7) Pediatric blood & cancer, 65(7). Wiley-Liss Inc. |
| ISSN: | 1545-5009 |
| Popis: | The Cooperative Ewing Sarcoma Study and the Late Effects Surveillance System of the Society for Paediatric Oncology and Haematology recommend a structured follow-up imaging protocol (FUIP) for patients with Ewing sarcoma (EwS) with decreasing frequency of imaging over the first 5 years. The present study aims to assess the effectiveness of the FUIP for EwS patients regarding survival after relapse. A retrospective multicenter analysis on 160 eligible patients with EwS recurrence was performed. Potential survival differences following recurrence diagnosis between patients with protocol-detected and symptomatic relapse were investigated using the Kaplan-Meier method. Additional subgroup analyses were performed on the relapse type. Overall survival (OS) was calculated from diagnosis of relapse to last follow-up or death. In the multicenter analysis, recurrence was detected by FUIP in 77 of 160 patients (48%) and due to symptoms in 83 patients (52%). Regarding the entire study population, OS was significantly superior in patients with protocol-detected relapse compared to patients with symptomatic relapse (median, 2.4 vs. 1.2 years; P < 0.001). In the subgroup analyses, patients whose lung recurrences were detected by the FUIP experienced longer survival after recurrence than those whose recurrences were detected symptomatically (P = 0.023). In the 83 symptomatic patients, pain was the most prevalent symptom of relapse (72%). FUIP may benefit survival in EwS relapse, especially in lung recurrence. Pain was the leading symptom of relapse |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text