C-C motif chemokine ligand 5 (CCL5) levels in gastric cancer patient sera predict occult peritoneal metastasis and a poorer prognosis
| Autor: | Qian Yao, Yan Ma, Yu-zhe Wei, Meizhuo Gao, Yanying Wang, Lining Tian, Hongjiang Song, Tie Wang, Meiyan Feng, Yingwei Xue |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine China medicine.medical_specialty Chemokine Pathology Gastroenterology CCL5 03 medical and health sciences Peritoneal Neoplasm 0302 clinical medicine stomatognathic system Predictive Value of Tests Stomach Neoplasms Internal medicine parasitic diseases Biomarkers Tumor medicine Humans Chemokine CCL5 Peritoneal Neoplasms Survival analysis Retrospective Studies biology business.industry virus diseases hemic and immune systems Retrospective cohort study General Medicine Middle Aged Prognosis Survival Analysis Occult stomatognathic diseases 030104 developmental biology 030220 oncology & carcinogenesis Predictive value of tests biology.protein Immunohistochemistry Female Surgery business |
| Zdroj: | International Journal of Surgery. 32:136-142 |
| ISSN: | 1743-9191 |
| Popis: | Gastric cancer is one of the most common cancers and the third leading cause of cancer death worldwide. A number of chemokines and cytokines play important roles in the progress of gastric cancer. The roles of C-C motif chemokine ligand 5 (CCL5) in gastric cancer remain unclear. Here, we retrospectively report an analysis of 105 patients with gastric cancer. Increased levels of CCL5 in circulation were correlated with more advanced T and N stages, poorly- or un-differentiated histological types, peritoneal metastasis, higher rates of residual tumor, and shorter survivals. Patients in the CCL5 High Group had stronger CCL5 immunohistochemistry (IHC) staining in tumor beds. Circulating CCL5 concentrations before surgery are a good biomarker for occult peritoneal metastasis. Elevated levels of serum CCL5, along with strong IHC CCL5 staining and poorly- or un-differentiated cancer are predictors for poorer outcomes. In conclusion, increased serum levels of CCL5 can be used to predict peritoneal dissemination and a poorer prognosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect