Structural Configuration of Blood Cell Membranes Determines Their Nonlinear Deformation Properties

Autor:	Elena Kozlova, Viktoria Sergunova, Vladimir Inozemtsev, Ekaterina Sherstyukova, Aleksandr Kozlov, Olga Gudkova, Aleksandr Chernysh
Rok vydání:	2022
Předmět:	Erythrocytes Article Subject General Immunology and Microbiology Neutrophils Elastic Modulus Cell Membrane General Medicine Cytoskeleton General Biochemistry Genetics and Molecular Biology
Zdroj:	BioMed Research International. 2022:1-19
ISSN:	2314-6141 2314-6133
DOI:	10.1155/2022/1140176
Popis:	The ability of neutrophils and red blood cells (RBCs) to undergo significant deformations is a key to their normal functioning. Disruptions of these processes can lead to pathologies. This work studied the influence of structural configuration rearrangements of membranes after exposure to external factors on the ability of native membranes of neutrophils and RBCs to undergo deep deformation. The rearrangement of the structural configuration of neutrophil and RBC membranes under the influence of cytological fixatives caused nonlinear deformation phenomena. There were an increase in Young’s modulus, a decrease in the depth of homogeneous bending, and a change in the distance between cytoskeletal junctions. Based on the results of the analysis of experimental data, a mathematical model was proposed that describes the process of deep bending of RBСs and neutrophil membranes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db16fc1aaebb5cc37e0b3d608e750d4 https://doi.org/10.1155/2022/1140176 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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