Production of 6-deoxy-13-cyclopropyl-erythromycin B by Saccharopolyspora erythraea NRRL 18643

Autor:	Hamish A. I. McArthur, Ellen L. McCormick, Mike Pacey, Thomas N. O'Connell, John C. Ruddock, John P. Dirlam, Paul A. Murphy, Maria S. Brown, Brook Knight Morse, Richard Gerald Wax, Dianne M. Rescek
Rok vydání:	1999
Předmět:	Cyclopropanes Pseudonocardiaceae Magnetic Resonance Spectroscopy Stereochemistry Carboxylic acid Microbial Sensitivity Tests chemistry.chemical_compound Drug Discovery Antibacterial agent Pharmacology chemistry.chemical_classification biology ATP synthase Molecular Structure biology.organism_classification Anti-Bacterial Agents Erythromycin 6-deoxy-13-cyclopropyl-erythromycin B Aglycone chemistry Biochemistry biology.protein Saccharopolyspora erythraea Macrolides Bacteria Saccharopolyspora
Zdroj:	The Journal of antibiotics. 52(8)
ISSN:	0021-8820
Popis:	Cyclopropane carboxylic acid was fed to Saccharopolyspora erythraea NRRL 18643 (6-deoxyerythromycin producer), resulting in the production of 6-deoxy-13-cyclopropyl-erythromycin B. These studies provide further evidence that deoxyerythronolide B synthase has a relaxed specificity for the starter unit.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db122089fa02833059677309da2751d https://pubmed.ncbi.nlm.nih.gov/10580387 Zobrazit plný text záznamu