Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via AMPK activation
Autor: | G. Babai-Shani, Arie Gruzman, Ella Meltzer-Mats, Guy Cohen, Olga Viskind, L. Pasternak, Jürgen Eckel, Erol Cerasi, Shlomo Sasson |
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Rok vydání: | 2014 |
Předmět: |
Glucose uptake
AMP-Activated Protein Kinases Pharmacology Catalysis Cell Line chemistry.chemical_compound Insulin-Secreting Cells Insulin Secretion Materials Chemistry medicine Animals Insulin Benzothiazoles Muscle Skeletal Thiazole Protein kinase A geography geography.geographical_feature_category Chemistry Metals and Alloys AMPK Skeletal muscle General Chemistry Islet Adenosine Rats Surfaces Coatings and Films Electronic Optical and Magnetic Materials Enzyme Activation Glucose medicine.anatomical_structure Biochemistry Benzothiazole Ceramics and Composites medicine.drug |
Zdroj: | Chem. Commun.. 50:11222-11225 |
ISSN: | 1364-548X 1359-7345 |
Popis: | Adenosine monophosphate-activated protein kinase (AMPK) has been identified as one of the major targets for antidiabetic drugs. This study describes two AMPK-activating agents 2-(benzo[d]thiazol-2-ylmethylthio)-6-ethoxybenzo[d]thiazole and 2-(propylthio)benzo[d]thiazol-6-ol, that increase the rate of glucose uptake in L6 myotubes and also augment glucose-stimulated insulin secretion in INS-1E β-cells and rat islets. We believe that such unique bi-functional compounds can be further used for the development of a new class of antidiabetic drugs. |
Databáze: | OpenAIRE |
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