Prevalence of prolonged QT interval in patients with HCV-related chronic liver disease
Autor: | Magdy Ismail, Yasser AbdelRahman, Mohamed El Kassas, Amr Abd El-Aal, Waleed M. Hassan, Housam M. Hassan, Mohamed-Naguib Wifi, Shimaa Afify Mansour, Mohamed Alboraie, Adel ElTahan, Dalia Omran, Ahmed Gaafar |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
medicine.medical_specialty
congenital hereditary and neonatal diseases and abnormalities lcsh:Diseases of the circulatory (Cardiovascular) system Cirrhosis FIB-4 score Hepatitis C virus QT prolongation 030204 cardiovascular system & hematology medicine.disease_cause Chronic liver disease Direct-acting antivirals Gastroenterology QT interval 03 medical and health sciences Liver disease 0302 clinical medicine Fibrosis Internal medicine medicine In patient 030212 general & internal medicine cardiovascular diseases business.industry Incidence (epidemiology) Research medicine.disease lcsh:RC666-701 cardiovascular system business circulatory and respiratory physiology |
Zdroj: | The Egyptian Heart Journal, Vol 71, Iss 1, Pp 1-7 (2019) The Egyptian Heart Journal |
Popis: | Background Hepatitis C virus (HCV) is a common disease in Egypt with a high socioeconomic burden and extra-hepatic manifestations as QT prolongation, but previous studies included mainly patients with advanced liver disease, so in this study, we aimed to delineate the prevalence of QT prolongation in early-stage HCV patients. Results The study included 874 HCV patients with early cirrhosis; in Child’s class A, 57 (6.5%) patients had prolonged QT interval corrected (QTc). There was significant higher proportion of cirrhotic patients in the prolonged QTc group (31.6%) vs. in the normal QTc group (11.5%). QTc was 424.39 ± 36.6 vs. 411.51 ± 32.89 ms in cirrhotic and non-cirrhotic patients, respectively (P, 0.001). There was significant higher proportion of Fibrosis 4 (FIB-4) ≥ 1.45 score in the prolonged QTc (77.2%) vs. in the normal QTc group (56.8%) (P, 0.003). QTc interval was 417.76 ± 34.12 ms in patients with FIB-4 score ≥ 1.45 vs. 406.78 ± 31.95 ms in those with FIB-4 < 1.45 (P, < 0.001). FIB-4 score value of 2.108 predicted prolonged QTc with a sensitivity of 63.2% and a specificity of 64.5% (P, < 0.001). Twenty-four patients of long QTc group sent ECGs after HCV eradication, and 19 patients (79%) showed QTc normalization. Conclusions HCV is associated with QTc prolongation even in patients with early chronic liver disease stages without significant fibrosis. Also, it is related to the degree of fibrosis and cirrhosis. At a cutoff value of 2.108, FIB-4 score can predict prolonged QTc. HCV eradication is associated with a high incidence of QTc normalization. |
Databáze: | OpenAIRE |
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