Toxicity of diphtheria toxin for lymphoblastoid cells is increased by conjugation to antilymphocytic globulin

Autor:	C. A. Hinson, D. C. Edwards, A. J. S. Davies, Alan J. Cumber, P. E. Thorpe, W. C. J. Ross
Rok vydání:	1978
Předmět:	Cytotoxicity Immunologic Diphtheria toxin Multidisciplinary biology Chemistry Lymphoblast Virology Cell Line Antigen-Antibody Reactions Antigen Cell culture Toxicity biology.protein Cancer research Cytotoxic T cell Chlorambucil Diphtheria Toxin Lymphocytes Antibody Cytotoxicity Antilymphocyte Serum
Zdroj:	Nature. 271:752-755
ISSN:	1476-4687 0028-0836
DOI:	10.1038/271752a0
Popis:	THERE is a pressing need in medicine for cytotoxic agents with tissue specificity. It may be possible to produce such agents by conjugating cytotoxic materials, themselves lacking inherent specificity, to antibodies directed against surface antigens peculiar to target cells. Various agents, including cytotoxic drugs1–7, radioactive materials8, radiosensitising agents9 and enzymes10–11 have been covalently coupled to antitumour antibodies in attempts to produce such antitumour agents but so far these have not consistently produced cures in tumour-bearing animals. We, like others12–16, have chosen to use diphtheria toxin because we consider that the paucity of tumour-specific antigens, accentuated, perhaps, by their restricted accessibility in solid tumours, necessitates the use of the most potent cytotoxins available.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da99f904f809aa69fb5fc4ebcd1b63b https://doi.org/10.1038/271752a0 Zobrazit plný text záznamu