Positive changes in femoral nerve morphometry in older rats following aerobic training
| Autor: | Danilo Sales Bocalini, Caio Cezar de Lima Maciel, Alexandra Carolina Canonica, Eliane Florencio Gama, Rosângela Cordeiro Garoto, Armando Bega, Romeu Rodrigues de Souza, Natalie Souza de Andrade, Ariana A. da Silva, Laura Beatriz Mesiano Maifrino, Angélica Castilho Alonso |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Photomicrography 0301 basic medicine Aging medicine.medical_specialty Neurofilament Population Biochemistry Random Allocation 03 medical and health sciences Myelin 0302 clinical medicine Endocrinology Femoral nerve Endurance training Physical Conditioning Animal Internal medicine Genetics medicine Animals Aerobic exercise Fiber Rats Wistar Axon education Molecular Biology Myelin Sheath education.field_of_study business.industry Cell Biology Axons Rats 030104 developmental biology medicine.anatomical_structure business Femoral Nerve 030217 neurology & neurosurgery |
| Zdroj: | Experimental Gerontology. 110:92-97 |
| ISSN: | 0531-5565 |
| Popis: | The objective of the present study was to analyze alterations of the femoral nerve of aged rats subjected to aerobic training. Wistar rats (12-mo of age) were divided in to two groups: S group (sedentary) and T group (trained). The exercise protocol were 16 weeks long. The groups were sacrificed at 16 months. Ultrafine sections of the femoral nerve have been used. There was no change in the body weight between the groups. T group showed a significant increase in myelinated fiber area, axon diameter, myelin sheath thickness and myelin fiber number compared with sedentary controls. In exercised trained animals, histograms of the frequency distribution of myelinated axons according to their areas showed increased number of medium and large fibers in relation to small fibers, which decreased in number. Aerobic training animals, showed the distribution of myelinated fiber population according to their area being bimodal, with the distribution shifted to the right, indicating increased fiber area. The T group showed a percent damage of large myelinated fibers significantly lower compared to controls. No significant difference was observed between the groups for the g-ratio. The T group also showed a significant increase in the number of microtubules and neurofilaments in myelinated fibers, which was not observed in S group. In conclusion, aerobic training improves nerve structure without evidence of nerve damage and produces an attenuation on the modifications in femoral nerve that develop in old age. |
| Databáze: | OpenAIRE |
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