Prolonged High-Dose Isoflurane for Refractory Status Epilepticus
| Autor: | Joseph D. Burns, David O. Warner, Eelco F. M. Wijdicks, Alejandro A. Rabinstein, Christopher J. Jankowski, Jennifer E. Fugate |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Time Factors Status epilepticus Drug Administration Schedule Central nervous system disease Epilepsy Status Epilepticus Thalamus Refractory Cerebellum medicine Humans Isoflurane medicine.diagnostic_test business.industry Persistent Vegetative State Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Hyperintensity Discontinuation Treatment Outcome Anesthesiology and Pain Medicine Child Preschool Anesthesia Anticonvulsants Female medicine.symptom business medicine.drug |
| Zdroj: | Anesthesia & Analgesia. 111:1520-1524 |
| ISSN: | 0003-2999 |
| DOI: | 10.1213/ane.0b013e3181f6da34 |
| Popis: | Isoflurane is an alternative treatment for refractory status epilepticus. Little is known regarding human toxicities caused by isoflurane. We present 2 patients with prolonged refractory status epilepticus treated with high concentrations of isoflurane who developed signal abnormalities on magnetic resonance imaging. Patient 1 was treated with isoflurane for 85 days with 1975.2% concentration-hours. Patient 2 was treated with isoflurane for 34 days with 1382.4% concentration-hours. Serial brain magnetic resonance images in both showed progressive T2 signal hyperintensity involving thalamus and cerebellum, which improved after discontinuation of isoflurane. These cases suggest that isoflurane may be neurotoxic when used in high doses for long time periods. |
| Databáze: | OpenAIRE |
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