[A Pharmacist's Query Avoiding Exacerbation of Adverse Effects in a Patient with Acyclovir Encephalopathy: A Case Report]

Autor: Tatsuya Tai, Kazunori Yamaguchi, Naohiro Kurokawa, Wataru Shinmura, Aki Matsubara, Masahiro Watanabe, Takahiro Motoki, Hiroaki Tanaka, Hitoshi Houchi, Shinji Kosaka
Rok vydání: 2022
Předmět:
Zdroj: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 142(7)
ISSN: 1347-5231
Popis: We report a haemodialysis patient with end-stage renal failure whom a pharmacist aided in the management of acyclovir (ACV) encephalopathy, which may have been related to valacyclovir hydrochloride (VACV) administered without sufficient dose reduction. The patient 78 years was admitted with a tentative diagnosis of varicella zoster viral meningitis. A pharmacist suspected ACV encephalopathy related to excessive VACV administration and raised a query with the attending physician. According to the pharmacist's proposal, ACV administration was discontinued and continuous hemodiafiltration (CHDF) was performed. On day 5 of hospitalisation, the consciousness disorder was improved. In this report, we showed the detailed CHDF conditions of the present case, and the contribution of a pharmacist to treating and avoiding ACV encephalopathy was discussed.
Databáze: OpenAIRE