Solving the preoperative breast MRI conundrum: design and protocol of the MIPA study
| Autor: | Mireille Van Goethem, Stefania Montemezzi, Julia Camps Herrero, Giovanni Di Leo, Gabor Forrai, Raffaele Ienzi, Marc B. I. Lobbes, Rubina M. Trimboli, Gianfranco Scaperrotta, Botond K. Szabó, Donna Taylor, Massimo Calabrese, José L. Raya-Povedano, Heike Preibsch, Stefanie Weigel, Margrethe S. Schlooz, Rossano Girometti, Marina Benito, Ritse M. Mann, Steven E. Harms, Marcos F. de Lima Docema, Jeroen Veltman, Francesco Sardanelli, Nehmat Houssami, Thomas H. Helbich, Chiara Zuiani, Sarah Hilborne, Corinne Balleyguier, Federica Pediconi, Catherine Depretto, Daniela Sacchetto, Enrico Cassano, Danubia A. de Andrade, Francesco Cartia, Massimo Bazzocchi, Ozden S. Ulus, Evelyn Wenkel, Peter Bult, Umit Aksoy Ozcan, Fiona J. Gilbert, Claudio Losio, Inge Marie Obdeijn, Paola Clauser |
|---|---|
| Přispěvatelé: | Gilbert, Fiona [0000-0002-0124-9962], Apollo - University of Cambridge Repository, Beeldvorming, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Radiology & Nuclear Medicine, Acibadem University Dspace |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_treatment
RECOMMENDATIONS 030218 nuclear medicine & medical imaging law.invention Breast neoplasms Breast-conserving surgery Magnetic resonance imaging Mastectomy Prospective studies 0302 clinical medicine Clinical Trial Protocols as Topic Randomized controlled trial law Breast MRI Breast Prospective Studies Prospective cohort study Neoadjuvant therapy Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17] medicine.diagnostic_test WOMEN General Medicine RESONANCE Middle Aged CONSERVING SURGERY CANCER Magnetic Resonance Imaging Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] 030220 oncology & carcinogenesis Female Radiology Reoperation medicine.medical_specialty Breast Neoplasms MUTATION CARRIERS 03 medical and health sciences Breast cancer Preoperative Care medicine Humans Radiology Nuclear Medicine and imaging METAANALYSIS Aged Computer. Automation business.industry 20-YEAR FOLLOW-UP 42 HEALTH SCIENCES::4206 Public health [ANZSRC FoR code] medicine.disease SCREENING MAMMOGRAPHY Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] Observational study business ADDITIONAL FINDINGS |
| Zdroj: | European Radiology, 30(10), 5427-5436. Springer, Cham European radiology European Radiology, 30(10), 5427-5436. Springer-Verlag European Radiology, 30, 5427-5436 European Radiology, 30, 10, pp. 5427-5436 European Radiology EUROPEAN RADIOLOGY r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) r-FISABIO. Repositorio Institucional de Producción Científica instname |
| ISSN: | 0938-7994 |
| Popis: | Contains fulltext : 225795.pdf (Publisher’s version ) (Closed access) Despite its high diagnostic performance, the use of breast MRI in the preoperative setting is controversial. It has the potential for personalized surgical management in breast cancer patients, but two of three randomized controlled trials did not show results in favor of its introduction for assessing the disease extent before surgery. Meta-analyses showed a higher mastectomy rate in women undergoing preoperative MRI compared to those who do not. Nevertheless, preoperative breast MRI is increasingly used and a survey from the American Society of Breast Surgeons showed that 41% of respondents ask for it in daily practice. In this context, a large-scale observational multicenter international prospective analysis (MIPA study) was proposed under the guidance of the European Network for the Assessment of Imaging in Medicine (EuroAIM). The aims were (1) to prospectively and systematically collect data on consecutive women with a newly diagnosed breast cancer, not candidates for neoadjuvant therapy, who are offered or not offered breast MRI before surgery according to local practice; (2) to compare these two groups in terms of surgical and clinical endpoints, adjusting for covariates. The underlying hypotheses are that MRI does not cause additional mastectomies compared to conventional imaging, while reducing the reoperation rate in all or in subgroups of patients. Ninety-six centers applied to a web-based call; 36 were initially selected based on volume and quality standards; 27 were active for enrollment. On November 2018, the target of 7000 enrolled patients was reached. The MIPA study is presently at the analytic phase. Key Points • Breast MRI has a high diagnostic performance but its utility in the preoperative setting is controversial. • A large-scale observational multicenter prospective study was launched to compare women receiving with those not receiving preoperative MRI. • Twenty-seven centers enrolled more than 7000 patients. The study is presently at the analytic phase. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink