In silico characterisation and phylogenetic analysis of Arabidopsis homologues of the human antiretroviral SERINC proteins

Autor:	Siarhei A. Dabravolski, Yury K. Kavalionak
Rok vydání:	2021
Předmět:	biology Phylogenetic tree In silico food and beverages Computational biology biology.organism_classification Computer Science Applications Serine Transmembrane domain Retrovirus Phylogenetics Arabidopsis Drug Discovery Arabidopsis thaliana
Zdroj:	International Journal of Computational Biology and Drug Design. 14:217
ISSN:	1756-0764 1756-0756
DOI:	10.1504/ijcbdd.2021.10040277
Popis:	Serine incorporator (SERINC) family proteins are well-known for their antiretroviral properties via strong inhibition of the human immunodeficiency viruses-1 (HIV-1) replication in human T-cells. SERINC proteins are highly conserved in all eukaryotes, representing 10-12 transmembrane domains. In the present study, for the first time, five SERINC homologues from the model plant Arabidopsis thaliana were analysed. We primarily focused on the comprehensive computational, structural and functional characterisation, phylogeny reconstruction. Further investigation on the SERINC proteins on plants will help to define their role in plant development, exact biochemical function and affected physiological processes. Also, it would enhance our comprehension of the evolutionally conserved mechanisms of antiretroviral protection, shared between yeast, plants and human. Potentially, plant SERINC domain-containing proteins could be used as a model to study antiretroviral response. Such knowledge could provide important insight into the creation of an effective antiretroviral vaccine for medical use.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9d250cbaeea7920f3de4bc5bec942f https://doi.org/10.1504/ijcbdd.2021.10040277 Zobrazit plný text záznamu