Transient deafferentation in humans induces rapid modulation of primary sensory cortex not associated with subcortical changes: a somatosensory evoked potential study
| Autor: | G.P. Zanette, Paolo Manganotti, C. Bonato, Alberto Polo, R. Testoni, Antonio Fiaschi, Michele Tinazzi, D. Volpato |
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| Přispěvatelé: | Tinazzi, M., Zanette, G., Polo, A., Volpato, D., Manganotti, Paolo, Bonato, C., Testoni, R., Fiaschi, A. |
| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
Adult
Time Factors Somatosensory system Evoked Potentials Somatosensory Humans Medicine Anaesthetic block Ulnar nerve Ulnar Nerve Somatosensory evoked potentials Cerebral Cortex Afferent Pathways Brain plasticity Neuronal Plasticity business.industry General Neuroscience Nerve Block Somatosensory Cortex Primary sensory cortex Anatomy Somatosensory evoked potential study Denervation Electric Stimulation Median nerve Median Nerve Peripheral Sensorimotor cortex Deafferentation Spinal Cord Somatosensory evoked potential Brainstem business Neuroscience Brain Stem |
| Popis: | Human somatosensory cortex (S1) is capable of rapid modification after temporary peripheral deafferentation but it is not known whether subcortical changes contribute to this modulation. We recorded spinal, brainstem and cortical somatosensory evoked potentials (SEPs) to median nerve stimulation following anaesthetic block of the ipsilateral ulnar nerve. Spinal N13 and subcortical P14, N18 potentials remained unchanged during the experiment. N20/P20, P27 and N30 cortical potentials, which are generated in different subareas of the S1 (N20/P20, N30 in area 3b; P27 in area 1), showed different increases in amplitude during the anaesthesia, which were more marked for N20/P20 and N30 than for P27 potentials. These results suggest that changes in S1 neural activity induced by transient deafferentation may be primarily intracortical in origin and appear to be segregated within the different subareas of the somatosensory cortex. Unmasking of pre-existing thalamo-cortical projections from median nerve territories, induced by ipsilateral ulnar nerve deafferentation, may be the mechanism underlying cortical SEP enhancement. |
| Databáze: | OpenAIRE |
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