Evaluation of mismatch negativity as a marker for language impairment in autism spectrum disorder

Autor: Trey Avery, Karen Froud, Guannan Shen, Dayna Moya Sepulveda, Chaille Maddox, Heather L. Green, Felicidad Garcia, Sommer Hassan, Melissa Randazzo Wagner, Paula Garcia, Lisa Levinson, Lauren C. Shuffrey
Rok vydání: 2018
Předmět:
Linguistics and Language
medicine.medical_specialty
Autism Spectrum Disorder
Cognitive Neuroscience
Mismatch negativity
Experimental and Cognitive Psychology
Sensory system
Electroencephalography
Audiology
behavioral disciplines and activities
050105 experimental psychology
Lateralization of brain function
030507 speech-language pathology & audiology
03 medical and health sciences
Speech and Hearing
Vowel
mental disorders
otorhinolaryngologic diseases
medicine
Humans
0501 psychology and cognitive sciences
Language Development Disorders
Evoked potential
Association (psychology)
Child
medicine.diagnostic_test
05 social sciences
LPN and LVN
medicine.disease
Acoustic Stimulation
Autism spectrum disorder
Child
Preschool
Evoked Potentials
Auditory
Speech Perception
0305 other medical science
Psychology
Zdroj: Journal of communication disorders. 87
ISSN: 1873-7994
Popis: Background The identification of an early and objective marker of language impairment in autism spectrum disorder (ASD) has the potential to lead to earlier language intervention for affected children. The mismatch negativity (MMN), a passive auditory evoked potential, offers insight into the brain’s ability to direct attention to novel sounds. Since exposure to speech is necessary for learning to map meaning onto phonemes, we predicted slower MMN responses to speech sounds would indicate presence of language impairment in ASD. Methods We explored the relationship between MMN latency in children ages 5–10 with ASD plus language impairment (ASD + LI), ASD minus language impairment (ASD–LI), and typically developing children (TD) during an auditory oddball experiment presenting speech and pure tone sounds. Results Contrary to our prediction, children with ASD + LI demonstrated decreased MMN latency in the left hemisphere in response to novel vowel sounds compared to children with ASD–LI and TD controls. Parent responses to the Sensory Experiences Questionnaire revealed that all participating individuals with ASD were hypersensitive to sounds. Conclusions Our results lend support to the theory that some children with ASD + LI have increased connectivity in primary sensory cortices at the expense of connectivity to association areas of the brain. This may account for faster speech sound processing despite low language scores in these children. Future studies should focus on individuals with language impairment and hyper-or hyposensitivity to sounds.
Databáze: OpenAIRE
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