Vitamin A: not required for adrenal steroidogenesis in rats
| Autor: | Laura V. O'Brien, K. A. Gruber, Robert Gerstner |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Vitamin
Male medicine.medical_specialty Multidisciplinary Progesterone Reductase Vitamin A Deficiency Hydroxysteroid Dehydrogenases Dehydrogenase Ascorbic Acid Biology Ascorbic acid Rats chemistry.chemical_compound Endocrinology Biosynthesis chemistry Internal medicine Adrenal Glands medicine Ascorbic Acid Deficiency Adrenal function Animals Corticosterone |
| Zdroj: | Science (New York, N.Y.). 191(4226) |
| ISSN: | 0036-8075 |
| Popis: | Previous work supporting the vitamin A dependency of adrenal function in rats neglected to take into account a secondary effect of the deficiency, a decrease in hepatic ascorbic acid biosynthesis. Vitamin A-depleted rats maintained on a diet free of ascorbate had a decrease in the activity of adrenal 3 beta-hydroxysteroid dehydrogenase, and extensive adrenocortical degeneration. The use of an ascorbate supplement prevented the symptoms. The results suggest that previous evidence for direct involvement of vitamin A in steroidogenesis may have been due to the production of a secondary deficiency, a chronic scorbutic condition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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