Possible links between COVID-19 and male fertility
| Autor: | Moses Agbomhere Hamed, RE Akhigbe |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
2019-20 coronavirus outbreak
General Veterinary Coronavirus disease 2019 (COVID-19) biology business.industry viruses Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) fungi lcsh:R virus diseases lcsh:Medicine Obstetrics and Gynecology Angiotensin-converting enzyme Plant Science Virology body regions sars-cov-2 covid-19 angiotensin converting enzyme steroidogenesis spermatogenesis Reproductive Medicine Male fertility biology.protein Medicine Animal Science and Zoology business |
| Zdroj: | Asian Pacific Journal of Reproduction, Vol 9, Iss 5, Pp 211-214 (2020) |
| ISSN: | 2305-0500 |
| DOI: | 10.4103/2305-0500.294662 |
| Popis: | The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may have a ripple effect that puts men at a risk of infertility. This article reviews the possible link between SARS-CoV-2 infection and male reproduction following speculations that the single- stranded RNA viruses could directly invade the testes. SARS-CoV-2 enters the human lung cells via angiotensin converting enzyme 2 (ACE2). ACEs, its products, angiotensin-(1-7), and its receptor, MAS receptor, are expressed in the testes. Although the binding of SAR-CoV-2 to ACE2 could lead to excess angiotensin II with possible enhanced inflammation, angiotensin II could also promote sperm motility. In addition, the pathophysiology of SAR-CoV-2, especially in relation to male fertility, is yet to be fully understood; the suppression of androgen observed in COVID-19 infected men calls for the need for andrological assessment in infected male. |
| Databáze: | OpenAIRE |
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