Cerebral vs. Cardiovascular Responses to Exercise in Type 2 Diabetic Patients
Autor: | Yu-Sok Kim, Björn J. P. van der Ster, Patrice Brassard, Niels H. Secher, Johannes J. van Lieshout |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Cardiac output Physiology Mini Review cerebral blood flow 030204 cardiovascular system & hematology lcsh:Physiology vascular conductance 03 medical and health sciences 0302 clinical medicine Physiology (medical) Diabetes mellitus Internal medicine cerebral metabolism medicine Aerobic exercise cerebral oxygenation Cerebral perfusion pressure lcsh:QP1-981 diabetes Vascular disease business.industry cardiac output Human brain Hypoxia (medical) medicine.disease medicine.anatomical_structure Cerebral blood flow Cardiology medicine.symptom business 030217 neurology & neurosurgery |
Zdroj: | Kim, Y S, van der Ster, B J P, Brassard, P, Secher, N H & van Lieshout, J J 2021, ' Cerebral vs. Cardiovascular Responses to Exercise in Type 2 Diabetic Patients ', Frontiers in Physiology, vol. 11, 583155 . https://doi.org/10.3389/fphys.2020.583155 Frontiers in Physiology, Vol 11 (2021) Frontiers in Physiology |
ISSN: | 1664-042X |
Popis: | The human brain is constantly active and even small limitations to cerebral blood flow (CBF) may be critical for preserving oxygen and substrate supply, e.g., during exercise and hypoxia. Exhaustive exercise evokes a competition for the supply of oxygenated blood between the brain and the working muscles, and inability to increase cardiac output sufficiently during exercise may jeopardize cerebral perfusion of relevance for diabetic patients. The challenge in diabetes care is to optimize metabolic control to slow progression of vascular disease, but likely because of a limited ability to increase cardiac output, these patients perceive aerobic exercise to be more strenuous than healthy subjects and that limits the possibility to apply physical activity as a preventive lifestyle intervention. In this review, we consider the effects of functional activation by exercise on the brain and how it contributes to understanding the control of CBF with the limited exercise tolerance experienced by type 2 diabetic patients. Whether a decline in cerebral oxygenation and thereby reduced neural drive to working muscles plays a role for “central” fatigue during exhaustive exercise is addressed in relation to brain’s attenuated vascular response to exercise in type 2 diabetic subjects. |
Databáze: | OpenAIRE |
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