CAUSE OF ANÆMIA IN MALARIA
| Autor: | L.E. Pettitt, A.W. Woodruff, V.E. Ansdell |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Erythrocytes
Anemia Plasmodium falciparum Plasmodium vivax Hemolysis Autoimmune Diseases Immune system Chloroquine medicine Humans Immune Complex Diseases Erythropoiesis biology Erythrocyte Membrane Complement System Proteins General Medicine medicine.disease biology.organism_classification Erythrophagocytosis Malaria Immunology Erythrocyte Count Anemia Hemolytic Autoimmune medicine.drug |
| Zdroj: | The Lancet. 313:1055-1057 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(79)92952-0 |
| Popis: | 51Cr studies showed that after complete eradication of malarial parasites erythrocyte life-span is reduced for 4-5 weeks and that the reduction is associated with the presence of complement-containing immune complexes on the red-cell surface. The rate of erythrophagocytosis in the spleen is increased during this period. 59Fe studies of erythropoiesis indicated a mild degree of marrow depression. A very important factor causing anaemia in malaria appears to be a complement-mediated immune process. |
| Databáze: | OpenAIRE |
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