Assessment of serum apelin and lipocalin-2 levels in patients with subclinical hypothyroidism

Autor: Mehmet Ali Cikrikcioglu, Sidika Kesgin, Reha Erkoc, Muharrem Kiskac, Mehmet Zorlu, Cumali Karatoprak, Cuneyt Ardic, Kemal Yildiz, Mustafa Cakirca
Přispěvatelé: KISKAÇ, MUHARREM
Rok vydání: 2014
Předmět:
Adult
Blood Glucose
Male
Thyroid Hormones
medicine.medical_specialty
Cross-sectional study
Endocrinology
Diabetes and Metabolism
Thyrotropin
Group B
Body Mass Index
ZORLU M.
KıSKAÇ M.
Karatoprak C.
KESGIN S.
CAKIRCA M.
YILDIZ K.
ARDIC C.
ÇıKRıKÇıOĞLU M.
ERKOÇ R.
-Assessment of serum apelin and lipocalin-2 levels in patients with subclinical hypothyroidism.-
Annales d-endocrinologie
cilt.75
ss.10-4
2014
chemistry.chemical_compound
Endocrinology
Hypothyroidism
Lipocalin-2
Proto-Oncogene Proteins
Internal medicine
medicine
Humans
Insulin
Subclinical infection
Metabolic Syndrome
Creatinine
integumentary system
business.industry
Acute-phase protein
General Medicine
Overweight
medicine.disease
Lipids
Lipocalins
Apelin
Cross-Sectional Studies
chemistry
Asymptomatic Diseases
Disease Progression
Intercellular Signaling Peptides and Proteins
Female
Metabolic syndrome
business
Body mass index
Acute-Phase Proteins
Zdroj: Annales d'Endocrinologie. 75:10-14
ISSN: 0003-4266
DOI: 10.1016/j.ando.2013.12.001
Popis: Objectives Subclinical hypothyroidism is the precursor to hypothyroidism because it has a tendency to transform into hypothyroidism. Subclinical hypothyroidism is considered one of the risk factors causing metabolic syndrome. Metabolic syndrome can be characterized by plasma levels of apelin and lipocalin-2, both released from adipocytes. In the present study, we aimed to measure serum apelin and lipocalin-2 levels of patients with subclinical hypothyroidism and compare them with serum apelin and lipocalin-2 levels from healthy individuals. Methods This was a cross-sectional study. A total of 80 subjects were enrolled in the study and divided into two groups: Group A included 39 patients (females, n = 34) diagnosed with subclinical hypothyroidism, and Group B (the control group) comprised 41 healthy volunteers (females, n = 38). Serum samples were obtained from each participant for the measurement of apelin and lipocalin-2. These were then stored at minus 80 °C until the time of analysis, when serum apelin and lipocalin-2 levels of the two groups were compared. Results Patients with subclinical hypothyroidism (Group A and Group B subjects [healthy controls]) were comparable with respect to gender, age, and body mass index (BMI) ( P = 0.412, P = 0.863, and P = 0.269, respectively), nor was there a statistically significant difference between groups in terms of apelin and lipocalin-2 levels ( P = 0.87, and P = 0.67, respectively). Apelin levels showed a positive and significant correlation with BMI ( P = 0.034). Serum lipocalin-2 levels showed significant positive correlations with BMI and creatinine levels ( P = 0.002, and P = 0.025, respectively). Conclusion In the present study, no significant difference of serum apelin and lipocalin-2 levels was observed between patients with subclinical hypothyroidism and healthy control subjects. Positive correlations were found, however, between serum apelin level and BMI as well as between serum lipocalin-2 and BMI and creatinine levels.
Databáze: OpenAIRE
Externí odkaz: