Patient-reported fatigue in patients with rheumatoid arthritis who commence biologic therapy: a longitudinal study
| Autor: | Gerd Karin Natvig, Heidi Øksnes Markussen, Hege Selheim Rinke, Clara Gram Gjesdal, Jörg Assmus |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Longitudinal study Allergy and Clinical Immunology Fatigue severity scale lcsh:Medicine Disease Nursing General Biochemistry Genetics and Molecular Biology Pharmacological treatment 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine medicine Fatigue Severity Scale In patient 030212 general & internal medicine Rheumatoid arthritis Fatigue 030203 arthritis & rheumatology business.industry General Neuroscience lcsh:R Repeated measures design Gender General Medicine medicine.disease Observational study General Agricultural and Biological Sciences business Biologic therapy |
| Zdroj: | PeerJ PeerJ, Vol 7, p e6771 (2019) |
| ISSN: | 2167-8359 |
| Popis: | Aims and objectives To examine changes in patient-reported fatigue, over a twelve month period, in rheumatoid arthritis patients who commence biologic treatment, and to identify possible predictors for such changes. Background Fatigue is a burdensome symptom for patients with rheumatoid arthritis. Despite biologics being effective in reducing disease activity, patients still report fatigue. Design A longitudinal observational study. Methods A total of 48 patients were enrolled in the study. Fatigue was measured by the Fatigue Severity Scale. Independent samples T-tests were used to test gender differences, and paired samples T-tests were used to measure differences between repeated measures. Bivariate and multiple regression analyses were used to examine potential predictors for changes in fatigue, such as age, sex, Disease Activity Score 28, pain and physical and emotional well-being. Results Forty-seven patients completed the study. From baseline to 12-month follow-up, fatigue decreased significantly in both women and men. Analyses of predictors were performed step-wise, and the final model included sex and physical well-being. The results from this final step showed that female sex was the only significant predictor for changes in fatigue. Conclusion Patients commencing biologic therapy reported a significant reduction in fatigue. Female sex was a significant predictor of changes in fatigue. Relevance to clinical practice Despite improvements in pharmacological treatment, patients with rheumatoid arthritis still report fatigue. This is a multifaceted health problem encompassing personal and emotional factors in addition to the clinical factors directly connected to the disease. |
| Databáze: | OpenAIRE |
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