A ten-year follow-up study of treatment outcome of craniopharyngiomas
| Autor: | Luigi Mariani, Andreas Raabe, Rolf W. Seiler, Emanuel Christ, Lukas Andereggen, Marwan El-Koussy, Robert H. Andres, Benjamin Hess |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty 610 Medicine & health 030209 endocrinology & metabolism Weight Gain Craniopharyngioma 03 medical and health sciences Postoperative Complications 0302 clinical medicine Risk Factors Interquartile range Clinical endpoint medicine Humans Pituitary Neoplasms Obesity Retrospective Studies business.industry Retrospective cohort study General Medicine Odds ratio medicine.disease Treatment Outcome Diabetes insipidus Female business Body mass index Diabetes Insipidus 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Andereggen, Lukas; Hess, Benjamin; Andres, Robert; El-Koussy, Marwan; Mariani, Luigi; Raabe, Andreas; Seiler, Rolf; Christ, Emanuel (2018). A ten-year follow-up study of treatment outcome of craniopharyngiomas. Swiss medical weekly, 148(w14521), w14521. EMH Schweizerischer Ärzteverlag 10.4414/smw.2018.14521 |
| ISSN: | 1424-3997 1424-7860 |
| Popis: | PURPOSE Craniopharyngioma-related hypothalamic obesity is a devastating complication with limited data on whether long-term follow-up should focus on problems other than endocrine deficiencies and weight gain. The primary endpoint was the assessment of predictors of hypothalamic obesity development; the secondary endpoint was the assessment of functional outcome (endocrine deficiencies, visual acuity) at long-term follow-up. METHODS This retrospective case-note study examined craniopharyngioma patients with at least 2 years of follow-up. Clinical, radiological and biochemical characteristics were assessed at diagnosis, postoperatively, and at last follow-up. RESULTS Thirty-two patients met the inclusion criteria. Median follow-up period was 9.8 years (range 2.2-33 years). Longitudinal changes in body mass index (BMI) were substantial (median ΔBMI/year was +0.48 kg/m2/year, interquartile range 0.28-1.33). The prevalence of patients with hypothalamic obesity had significantly increased at last follow-up (45 vs 4%; p = 0.003). Long-term pituitary deficiencies remained high. Diabetes insipidus was common (66% vs 34%, p |
| Databáze: | OpenAIRE |
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