Interferon decreases serum lipid peroxidation products of hepatitis C patients
| Autor: | Angel Raya, Joaquín Romá, Miguel A. Serra, J M Rodrigo, Francisco J. Romero, Victoria Higueras |
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| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Thiobarbituric acid HIV Infections Thiobarbituric Acid Reactive Substances Biochemistry Gastroenterology Hepatitis Lipid peroxidation chemistry.chemical_compound Interferon Physiology (medical) Internal medicine TBARS Humans Medicine In patient Hepatitis Chronic Superoxide Dismutase business.industry Hepatitis C medicine.disease Lipids chemistry Concomitant Acute Disease Immunology Interferons Lipid Peroxidation business medicine.drug |
| Zdroj: | Free Radical Biology and Medicine. 16:131-133 |
| ISSN: | 0891-5849 |
| DOI: | 10.1016/0891-5849(94)90250-x |
| Popis: | Thiobarbituric acid reactive substances (TBARS) concentration in serum has been determined in healthy subjects and in patients suffering acute hepatitis and chronic cases of hepatitis C. Treatment with interferon of the chronic active hepatitis C patients, 5 × 10 6 U three times a week during 2 months, led in those patients whose SGPT activity normalized in serum, to a concomitant decrease in serum TBARS content. The possible theoretical involvement of peroxidation and antioxidants in this beneficial effect of interferon in hepatitis C patients is discussed. The results presented confirm the value of TBARS as laboratory test in the management of liver diseases and as a useful tool for the study of pathogenic and/or therapeutic mechanisms of this viral infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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