Radioimmunometric assay of B-type natriuretic peptide (BNP) in heart transplantation: correlation between BNP determinations and biopsy grading of rejection
| Autor: | J L Pérez-Pastor, J F Martí, M Palencia, P. Bello, Luis Martínez-Dolz, F Vera, Chirivella M, Miguel A. Arnau, Ana Osa, A. Mateo, Luis Almenar, Joaquín Rueda, I Hervás |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Adolescent medicine.drug_class medicine.medical_treatment Statistics as Topic Radioimmunoassay Sensitivity and Specificity Severity of Illness Index Endomyocardial biopsy Correlation Ventricular Dysfunction Left Internal medicine Severity of illness Biopsy Natriuretic Peptide Brain Natriuretic peptide Medicine Humans Radiology Nuclear Medicine and imaging Radionuclide Imaging Grading (tumors) Aged Heart transplantation medicine.diagnostic_test business.industry Reproducibility of Results General Medicine Middle Aged Brain natriuretic peptide Cardiology Heart Transplantation Female business |
| Zdroj: | Nuclear medicine communications. 24(8) |
| ISSN: | 0143-3636 |
| Popis: | The aim of this study was to determine whether elevated brain natriuretic peptide (BNP) levels after heart transplantation are correlated with the severity of rejection by using endomyocardial biopsy (EMB) and echocardiographic parameters indicative of ventricular function of the transplanted heart. This was an observational study of 80 orthotopic heart transplant recipients (11 women and 69 men; mean age 53+/-11 years). BNP determinations were performed within 48 h of endomyocardial biopsy. The echocardiographic study and BNP determination were also performed in a group of healthy volunteers. We found significantly higher BNP mean levels in heart transplant patients than in healthy volunteers (volunteers, 16.7+/-16.2 pg.ml-1; transplant, 213.4+/-268.6 pg.ml-1; P |
| Databáze: | OpenAIRE |
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