Early retinal neurodegeneration in preclinical diabetic retinopathy: a multifactorial investigation
| Autor: | Ibrahim Toprak, Semin Fenkci, Cigdem Martin, Volkan Yaylali, Guzin Fidan Yaylali |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Retinal Ganglion Cells
genetic structures chemistry.chemical_compound 0302 clinical medicine Nerve Fibers diabetic patient middle aged Medicine hyperlipidemia hemoglobin A1c non insulin dependent diabetes mellitus adult Neurodegeneration Diabetic retinopathy diabetic retinopathy female spectral domain optical coherence tomography Tomography Optical Coherence medicine.medical_specialty hypertension microalbuminuria retinal nerve fiber layer thickness retina fovea Article 03 medical and health sciences male preclinical study Ophthalmology Humans cross-sectional study In patient controlled study human business.industry Significant difference Type 2 Diabetes Mellitus Retinal medicine.disease major clinical study eye diseases Cross-Sectional Studies chemistry Diabetes Mellitus Type 2 Metabolic control analysis retina degeneration 030221 ophthalmology & optometry Microalbuminuria sense organs business 030217 neurology & neurosurgery |
| Zdroj: | Eye (Lond) |
| Popis: | Background/Objectives: To investigate effects of microalbuminuria (MA), diabetes duration, glycosylated haemoglobin (HbA1c) level, hypertension (HT) and/or hyperlipidaemia (HL) coexistence on retinal layers in diabetic patients without diabetic retinopathy (DR) using spectral-domain optical coherence tomography (SD-OCT). Subjects/Methods: This cross-sectional study involved 95 (45 had MA and 50 had no MA) patients with type 2 diabetes mellitus (DM) without DR and 91 age- and gender-matched non-diabetic controls. Macular and peripapillary SD-OCT measurements (Heidelberg Engineering GmbH, Heidelberg, Germany), DM duration, HbA1c levels and presence of HT and/or HL were used for statistical analyses. Results: The MA (+), MA (−) and control groups had similar age and gender distribution (p > 0.05). The differences in SD-OCT measurements among the MA (+), MA (−) and control groups were insignificant (p > 0.05). However, diabetic patients (n = 95) had significantly thinner inferior-temporal peripapillary retinal nerve fibre layer (RNFL) (p = 0.042) than in the controls (n = 91). Superior peripapillary RNFL was significantly thinner in patients with an HbA1c level > 7% (p = 0.049). However, 3 mm-nasal, temporal and superior perifoveal thicknesses were significantly lower in patients with DM duration over 10 years (p < 0.05). HT and/or HL coexistence did not lead a significant difference in SD-OCT parameters among the groups. Conclusions: In diabetic patients without DR, peripapillary inferior-temporal RNFL thinning might be an early sign of neuroretinal degeneration and it seems to be independent from vascular endothelial damage (MA). Poor metabolic control appears to lead superior peripapillary RNFL thinning, while perifoveal thicknesses tend to decrease with longer DM duration. © 2019, The Author(s), under exclusive licence to The Royal College of Ophthalmologists. |
| Databáze: | OpenAIRE |
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