Female fertility preservation: Impact of cancer on ovarian function and oocyte quality
| Autor: | Rocco Rago, M. Gallo, Emanuele Licata, Gemma Paciotti, Caterina Meneghini, Antonella Guarino, Michele Carlo Schiavi, Maria Giulia Ferrante, C. Fabiani, V. Spina, Donatella Caserta |
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| Rok vydání: | 2021 |
| Předmět: |
Infertility
Male medicine.medical_treatment Oocyte Retrieval Controlled ovarian hyperstimulation Fertilization in Vitro Chorionic Gonadotropin Human chorionic gonadotropin Andrology 03 medical and health sciences 0302 clinical medicine Ovulation Induction Neoplasms medicine Humans 030212 general & internal medicine Fertility preservation Prospective Studies Prospective cohort study 030219 obstetrics & reproductive medicine In vitro fertilisation business.industry Obstetrics and Gynecology Cancer Fertility Preservation General Medicine medicine.disease Oocyte medicine.anatomical_structure Oocytes Female business Infertility Female |
| Zdroj: | International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and ObstetricsREFERENCES. 156(1) |
| ISSN: | 1879-3479 |
| Popis: | OBJECTIVE To evaluate the influence of cancer on ovarian response and oocyte quality in controlled ovarian hyperstimulation (COH). METHODS This prospective study conducted at the Physiopathology of Reproduction and Andrology Unit of Sandro Pertini Hospital enrolled 82 cancer patients undergoing controlled ovarian stimulation (COH) cycles for fertility preservation, and age- and date-matched controls undergoing COH for in vitro fertilization for male-factor infertility from June 2016 to November 2019. The interventions performed were COH, oocyte retrieval, and quality evaluation. Main outcome measures were maximal estradiol levels on the day of human chorionic gonadotropin administration, duration of stimulation, total amount of gonadotropins administered, number of oocytes retrieved, and rates of metaphase 2 oocytes and abnormal oocytes. All data were analyzed using the Statistical Package for the Social Sciences (IBM Corp., Armonk, NY, USA) 22.0. RESULTS Intergroup comparisons (82 cancer patients and 180 patients in control group) showed a significant difference in ovarian response, especially for a significant higher number of abnormal oocytes in cancer patients (P |
| Databáze: | OpenAIRE |
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