Efficacy of a novel extract of fenugreek seeds in alleviating vasomotor symptoms and depression in perimenopausal women: A randomized, double-blinded, placebo-controlled study

Autor:	Jyoti Rao, Krishnakumar Im, Balu Maliakel, Aman Khanna, S. Syam Das, Febi John, Jestin V Thomas
Rok vydání:	2020
Předmět:	030309 nutrition & dietetics Osteoporosis Biophysics Placebo-controlled study Physiology Placebo 03 medical and health sciences 0404 agricultural biotechnology Sex hormone-binding globulin Double-Blind Method Diabetes mellitus medicine Humans Adverse effect Pharmacology 0303 health sciences biology Vasomotor business.industry Depression Plant Extracts 04 agricultural and veterinary sciences Cell Biology medicine.disease 040401 food science Perimenopause Trigonella Hot Flashes biology.protein Female Sexual function business Food Science
Zdroj:	Journal of food biochemistryREFERENCES. 44(12)
ISSN:	1745-4514
Popis:	The present randomized, double-blinded, placebo-controlled study investigated the effect of a standardized fenugreek extract (FHE) on perimenopausal discomforts and its influence on hormonal balance and safety. Healthy women characterized with perimenopausal symptoms (n = 48), as assessed by MRS questionnaire, were randomized either to FHE (n = 24) or placebo (n = 24) and supplemented with 250 mg × 2/day for 42 days. Both inter and intra-group comparison revealed a significant improvement in somatic, psychological, and urogenital scores in FHE group, especially for hot flashes (25.9%), night sweats (26.5%), depression (31.8%), and insomnia (21.6%). Further hormone analysis revealed an enhancement in serum estradiol (18.9%), free testosterone (38.2%), and progesterone (19.9%) concentrations and a significant decrease in FSH (38.2%) and SHBG (21.1%) concentrations toward establishing a hormonal balance among FHE-group; without significant changes in other clinical safety parameters. Thus, FHE supplementation offered a significant reduction in vasomotor effects and depression in perimenopausal women, without any adverse effects PRACTICAL APPLICATIONS: Fenugreek is a popular kitchen spice and Ayurvedic medicine for a variety of health conditions including diabetes, hypercholesterolemia, hepatotoxicity, gastritis, and also for a variety of hormone-related health conditions such as sexual functions, lactation, osteoporosis, PCOS, and post/perimenopausal discomforts. Fenugreek is rich in alkaloids, steroidal saponins, flavonoids and 4-hydroxyisoleucine. The present randomized-controlled study investigated the plausible application of a standardized hydro-ethanolic extract of fenugreek seeds (FHE) having a unique 3:1 ratio for protodioscin to trigonelline in the management of perimenopausal discomforts. It was observed that FHE at a dosage of 250 mg × 2/day for 42 days significantly reduced the discomforts, especially vasomotor symptoms and depression, and helped to attain a hormonal balance without any adverse effects or deviations in clinical safety parameters. Thus, FHE could be a potential natural agent for the management of post and perimenopausal discomforts and has to be explored in future studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8d186db4f3816fac36e42d79ea42d3 https://pubmed.ncbi.nlm.nih.gov/33025616 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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