Maternal diabetes and childhood cancer risks in offspring: two population-based studies

Autor: Xiwen Huang, Johnni Hansen, Pei-Chen Lee, Chia-Kai Wu, Noah Federman, Onyebuchi A. Arah, Chung-Yi Li, Jorn Olsen, Beate Ritz, Julia E. Heck
Přispěvatelé: HAL UVSQ, Équipe, University of California [Los Angeles] (UCLA), University of California (UC), Danish Cancer Society Research Center [Copenhagen, Denmark] (DCSRC), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, National Cheng Kung University (NCKU), David Geffen School of Medicine [Los Angeles], University of California (UC)-University of California (UC), Aarhus University [Aarhus], University of North Texas (UNT), National Institutes of Health, NIH: R21CA175959, Alex's Lemonade Stand Foundation for Childhood Cancer, ALSF: 17-01882, The Danish study was supported by a grant from the US National Institutes of Health (R21CA175959). The Taiwanese study was supported by a grant from Alex’s Lemonade Stand Foundation (grant 17-01882).
Rok vydání: 2021
Předmět:
Zdroj: British Journal of Cancer
British Journal of Cancer, 2022, 127 (10), pp.1837-1842. ⟨10.1038/s41416-022-01961-w⟩
Huang, X, Hansen, J, Lee, P C, Wu, C K, Federman, N, Arah, O A, Li, C Y, Olsen, J, Ritz, B & Heck, J E 2022, ' Maternal diabetes and childhood cancer risks in offspring : two population-based studies ', British Journal of Cancer, vol. 127, no. 10, pp. 1837-1842 . https://doi.org/10.1038/s41416-022-01961-w
ISSN: 1532-1827
0007-0920
DOI: 10.1038/s41416-022-01961-w⟩
Popis: Background The effect of maternal diabetes on childhood cancer has not been widely studied. Methods We examined this in two population-based studies in Denmark (N = 6420 cancer cases, 160,484 controls) and Taiwan (N = 2160 cancer cases, 2,076,877 non-cases) using logistic regression and Cox proportional hazard regression adjusted for birth year, child’s sex, maternal age and birth order. Results Gestational diabetes in Denmark [odds ratio (OR) = 0.98, 95% confidence interval (CI): 0.71–1.35] or type II and gestational diabetes in Taiwan (type II: hazard ratio (HR) = 0.81, 95% CI: 0.63–1.05; gestational diabetes: HR = 1.06, 95% CI: 0.92–1.22) were not associated with cancer (all types combined). In Denmark, maternal type I diabetes was associated with the risk of glioma (OR = 2.33, 95% CI: 1.04–5.22), while in Taiwan, the risks of glioma (HR = 1.59, 95% CI: 1.01–2.50) were elevated among children whose mothers had gestational diabetes. There was a twofold increased risk for hepatoblastoma with maternal type II diabetes (HR = 2.02, 95% CI: 1.02–4.00). Conclusions Our results suggest that maternal diabetes is an important risk factor for certain types of childhood cancers, emphasising the need for effective interventions targeting maternal diabetes to prevent serious health effects in offspring.
Databáze: OpenAIRE
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