New ultrastructural marker in hepatocytes in non-A, non-B viral hepatitis
| Autor: | Valeer Desmet, J. Mortelmans, J. Fevery, C. Wolf‐Peeters, M. J. Stapel, F. Callea, G. Groote, Jan De Groote, J. Desmyter, R. Vos |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Hepatitis Viral Human Pan troglodytes Fluorescent Antibody Technique Biology Endoplasmic Reticulum Immunofluorescence Fibrinogen medicine Animals Humans Antiserum Hepatitis Hepatology medicine.diagnostic_test Endoplasmic reticulum Hepatitis C Hepatitis B medicine.disease Virology Liver Viral hepatitis medicine.drug |
| Zdroj: | Liver. 2:35-44 |
| ISSN: | 0106-9543 |
| Popis: | — A new ultrastructural cytoplasmic marker designated as type 2, and distinct from type 1 previously associated with NA-NB hepatitis in chimpanzees, was found in hepatocytes of two patients and of one experimentally infected chimpanzee. These cases represent a minority of all cases we studied as presumed NA-NB viral hepatitis. Type 2 marker consists of tubular structures composed of an assembly of ring-like units coated with smaller uniform fragments, accumulated in different patterns in dilated cisternae of the endoplasmic reticulum. Preliminary data using immunofluorescence with NA-NB hepatitis convalescent serum and antiserum against fibrinogen are reported. Type 2 marker may represent a different agent or a different reaction pattern to one agent of NA-NB viral hepatitis. Its features are compared with those of hepatitis B. |
| Databáze: | OpenAIRE |
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