A mathematical model of protein subunits COVID-19 vaccines
Autor: | Samaneh Gholami, Chapin S. Korosec, Suzan Farhang-Sardroodi, David W. Dick, Morgan Craig, Mohammad Sajjad Ghaemi, Hsu Kiang Ooi, Jane M. Heffernan |
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Jazyk: | angličtina |
Rok vydání: | 2024 |
Předmět: |
Statistics and Probability
General Immunology and Microbiology SARS-CoV-2 Applied Mathematics Neutralizing Antibody (NAb) mathematical modeling COVID-19 General Medicine General Biochemistry Genetics and Molecular Biology adaptive immune response protein subunit-based vaccine Modeling and Simulation IgG antibody General Agricultural and Biological Sciences |
Popis: | We consider a general mathematical model for protein subunit vaccine with a focus on the MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2, and use the model to study immunological outcomes in the humoral and cell-mediated arms of the immune response from vaccination. The mathematical model is fit to vaccine clinical trial data. We elucidate the role of Interferon-𝛾 and Interleukin-4 in stimulating the immune response of the host. Model results, and results from a sensitivity analysis, show that a balance between the T𝐻 1 and T𝐻 2 arms of the immune response is struck, with the T𝐻 1 response being dominant. The model predicts that two-doses of the vaccine at 28 days apart will result in approximately 85% humoral immunity loss relative to peak immunity approximately 6 months post dose 1. |
Databáze: | OpenAIRE |
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