The role of the histones H3K9ac, H3K9me3, HP1γ, and H3K36me3 in oral squamous cell carcinoma loco-regional metastasis and relapse
| Autor: | Sérgio Vitorino Cardoso, Marília Ferreira Andrade, Tássio Edno Atanásio Pitorro, Adriano Mota Loyola, Paulo Rogério de Faria, Juliana Moreira De Almeida Sant’Ana, João Paulo Silva Servato, Flávia Sayuri Matsuo, Alberto S. Moraes |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Lymph node metastasis Pathology and Forensic Medicine Metastasis Histones 03 medical and health sciences 0302 clinical medicine Gene expression Biomarkers Tumor medicine Overall survival Humans Basal cell Neoplasm Metastasis Aged Retrospective Studies Aged 80 and over Tumor size biology Squamous Cell Carcinoma of Head and Neck business.industry Cell Biology Middle Aged Prognosis medicine.disease Survival Rate stomatognathic diseases 030104 developmental biology Histone 030220 oncology & carcinogenesis biology.protein Cancer research Immunohistochemistry Female Mouth Neoplasms Neoplasm Recurrence Local business |
| Zdroj: | Pathology - Research and Practice. 216:153201 |
| ISSN: | 0344-0338 |
| DOI: | 10.1016/j.prp.2020.153201 |
| Popis: | Molecular markers with unequivocal significance in predicting cervical lymph node metastasis of oral squamous cell carcinoma (OSCC) has not yet been identified. Histones are DNA-binding proteins that can regulate gene expression, and some studies have shown that such proteins are implicated with tumor development and progression. This study aimed to investigate the expression of some histone modifications in OSCC and their roles in cervical lymph node metastasis. To address this goal, H3K9ac, H3K9me3, HP1γ, and H3K36me3 expression levels were investigated immunohistochemically in a retrospective metastatic and non-metastatic OSCC samples. We analyzed the association between these markers with clinical-pathological data and survival rates. Hyperacetylation of H3K9ac was associated with cervical lymph node metastasis and local relapse. High expression levels of H3K9m3 were related to age and symptomatology. Furthermore, it was also found a statistically significant association between high HP1γ-expressing tumors and tumor size. However, no markers were associated with reduced overall survival rate. Our results suggest that covalent histone modifications contribute to OSCC behavior, and H3K9ac may play a critical role in OSCC-derived cervical lymph node metastasis. |
| Databáze: | OpenAIRE |
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