Proarrhythmic Manifestations of Neuromuscular Dystrophinopathies
Autor: | John N. Makaryus, Haisam Ismail, Nicholas Chan, Amgad N. Makaryus, Daniel E. Huddleston, John N. Catanzaro |
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Rok vydání: | 2020 |
Předmět: |
Pediatrics
medicine.medical_specialty business.industry Arrhythmias Cardiac General Medicine Disease 030204 cardiovascular system & hematology medicine.disease Pathophysiology Muscular Dystrophy Duchenne 03 medical and health sciences 0302 clinical medicine Pharmacotherapy medicine Humans In patient 030212 general & internal medicine Muscular dystrophy Cardiology and Cardiovascular Medicine business |
Zdroj: | Cardiology in Review. 29:68-72 |
ISSN: | 1061-5377 |
Popis: | Muscular dystrophy has been an elusive term ever since it was first described in the 19th century. Introduced in 1891 by Wilhelm Heinrich Erb, muscular dystrophy has been classified as part of a larger group of genetically determined, progressive degenerative neuromuscular disorders termed "dystrophinopathies." Cardiac arrhythmias may occur during the neurologic course of the disease. Although descriptions of the dystrophinopathies have been reported in the literature, few articles address the use of antiarrhythmic pharmacotherapy in patients with muscular dystrophy. We discuss the pathophysiology of the most common dystrophinopathies, their proarrhythmic sequelae, and the therapeutic use of antiarrhythmic agents in the clinical setting. |
Databáze: | OpenAIRE |
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