Cardiovascular dysfunction and oxidative stress following human contamination by fluoride along with environmental xenobiotics (CdPb) in the phosphate treatment area of Togo, West Africa
| Autor: | Gabriel Lazar, Mamatchi Melila, Mabozou Kpemissi, Ganeshkumar Arumugam, Awaga Kwami Lumo, Rajaram Rajendran, Agbere Sadikou, Kou’santa Amouzou |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Systole chemistry.chemical_element Blood Pressure 010501 environmental sciences medicine.disease_cause 01 natural sciences Biochemistry Antioxidants Phosphates Xenobiotics Inorganic Chemistry Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound Fluorides 0302 clinical medicine Diastole Malondialdehyde medicine Humans 0105 earth and related environmental sciences Cadmium Triglyceride Geography Phosphate Oxidative Stress chemistry Lead Cardiovascular Diseases Environmental chemistry Togo Toxicity Hypertension Molecular Medicine Female Xenobiotic Environmental Pollution Fluoride 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 56 |
| ISSN: | 1878-3252 |
| Popis: | In Togo, the phosphate ore mill discharges waste containing xenobiotics like cadmium, lead and fluoride. If the role of heavy metals in the appearance of pathologies is known, the role of fluoride remains to be studied alongside xenobiotics. This study tested the hypothesis that the toxicity of fluoride contributes, along with heavy metals, to physiological dysfunction. In this process, we have studied the variation in the parameters of cardiovascular functioning, depending on the level of human contamination by fluoride and xenobiotics. The concentration of Cd and Pb in blood samples were determined by AAS and fluoride by titanium-chloride method. Lipid peroxidation, the total antioxidant potential of collected blood samples and the parameters of cardiovascular dysfunction were also measured. Cd, Pb and F contents and lipid peroxidation were found to be significantly elevated in polluted areas than control zone as well as total cholesterol, LDL and triglyceride. HDL and antioxidant potential of blood decreased in the polluted areas. Correlation tests showed that fluoride levels are related to variations in the bio-indicators of high blood pressure and oxidative stress (R varied from 0.354 to 0.907). Togo phosphate treatment leads to human contamination with fluoride, along with Cd and Pb, increasing the risk of cardiovascular dysfunction and oxidative stress. |
| Databáze: | OpenAIRE |
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