Membrane Permeability Modifications Are Involved in Antibiotic Resistance in Klebsiella pneumoniae
| Autor: | Jacqueline Chevalier, Annie Eyraud, Monique Malléa, Jean-Marie Pagès |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Klebsiella
Cell Membrane Permeability Membrane permeability medicine.drug_class Klebsiella pneumoniae Cephalosporin Biophysics Microbial Sensitivity Tests Biochemistry beta-Lactamases Microbiology Antibiotic resistance Anti-Infective Agents medicine Molecular Biology Cephalosporin Resistance biology Chemistry Drug Resistance Microbial Cell Biology biochemical phenomena metabolism and nutrition biology.organism_classification Anti-Bacterial Agents Imipenem Porin Efflux Bacterial Outer Membrane Proteins Norfloxacin |
| Zdroj: | Biochemical and Biophysical Research Communications. 274:496-499 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.2000.3159 |
| Popis: | Two Klebsiella pneumoniae strains selected according to their high cross-resistance pattern to cephalosporins were characterized by (i) outer membrane protein content such as OmpA or nonspecific porins, (ii) MICs of various cephalosporins and unrelated antibiotics, (iii) β-lactamase production, and (iv) active efflux of fluoroquinolones. An association of porin deficiency and β-lactamase production induced a noticeable cephalosporin resistance. In addition to these mechanisms, the presence of an active efflux participating in high-level fluoroquinolone resistance was identified in one strain. The decrease of antibiotic uptake associated with efflux explains the Klebsiella adaptation against the drugs present in the environment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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