Radiation changes in the liver, spleen, and pancreas: imaging findings

Autor: Chusilp Charnsangavej, Sidney Wallace, Anne Cinqualbre
Rok vydání: 1994
Předmět:
Zdroj: Seminars in roentgenology. 29(1)
ISSN: 0037-198X
Popis: T HE EFFECTS OF radiation on the solid viscera in the upper abdomen (liver, spleen, and pancreas) are well-known to radiation oncologists. 1-6 The clinical presentation of the effects and pathological changes in the radiated organs depend on several factors, including whether there was whole-organ or partial-organ irradiation, the dose and technique of the radiotherapy, and the length of time after radiotherapy. Radiation oncologists have always attempted to avoid complications of radiation injury by dose limitation when the whole organ is radiated, limited fields of radiation with appropriate blocking, and prolongation of the treatment period when necessary. As a result of this care, acute toxicity of major organs in the upper abdomen from radiation is rare. Radiation therapy is currently used for treatment of several solid tumors in the upper abdomen. Among these are carcinoma of the bile duct and gallbladder, ductal carcinoma of the pancreas, and lymphoma. Extended field radiotherapy is used for cervical cancer and occasionally testicular malignancies. The radiation portals for such therapy are more likely to affect the liver, spleen, and pancreas. A small portion of the anterior aspect of the liver is generally included in chest wall radiation for right-sided breast cancer. Radiation changes in these organs may then be seen in imaging studies as part of follow-up and may have no clinical significance. However, recognition of these changes is important so that they will not be mistaken for other pathological conditions. This review describes radiation changes in the liver, spleen, and pancreas, emphasizing the findings with computed tomography (CT) because CT is the most commonly used imaging modality for the follow-up of patients who have received radiotherapy to the upper abdomen.
Databáze: OpenAIRE