Metabolic Effects of Glucose-Fructose Co-Ingestion Compared to Glucose Alone during Exercise in Type 1 Diabetes
| Autor: | Luc Tappy, Robin Rosset, Nicola Pasi, Christian Speck, Patrick Kempf, Thomas Zueger, Matthias Wilhelm, Ayse Sila Dokumaci, Christoph Stettler, Lia Bally, Tania Buehler, Hannah Loher, Carlos Ciller, Katrin Feller, Christoph Hans Boesch |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Blood Glucose
Male type 1 diabetes medicine.medical_treatment carbohydrates glucose substrate oxidation exercise fructose glycaemia Eating chemistry.chemical_compound 0302 clinical medicine Insulin Ingestion 2. Zero hunger Nutrition and Dietetics Glycogen Muscles lcsh:Nutrition. Foods and food supply Adult medicine.medical_specialty lcsh:TX341-641 610 Medicine & health 030209 endocrinology & metabolism Fructose Biology Article Young Adult 03 medical and health sciences Oxygen Consumption Diabetes mellitus Internal medicine Dietary Carbohydrates medicine Humans Lactic Acid Exercise Type 1 diabetes Glucose Metabolism Diabetes 030229 sport sciences medicine.disease Dietary Fats Hormones Bicycling Diet Sports Nutritional Physiological Phenomena Diabetes Mellitus Type 1 Endocrinology chemistry Food Science Hormone |
| Zdroj: | Nutrients; Volume 9; Issue 2; Pages: 164 Nutrients Nutrients, vol. 9, no. 2, pp. 1-13 Bally, Lia; Kempf, Patrick; Zueger, Thomas; Speck, Christian; Pasi, Nicola; Ciller, Carlos; Feller, Katrin; Loher, Hannah; Rosset, Robin; Wilhelm, Matthias; Boesch, Christoph; Buehler, Tania; Dokumaci, Ayse S.; Tappy, Luc; Stettler, Christoph (2017). Metabolic Effects of Glucose-Fructose Co-Ingestion Compared to Glucose Alone during Exercise in Type 1 Diabetes. Nutrients, 9(2) Molecular Diversity Preservation International MDPI 10.3390/nu9020164 Europe PubMed Central Nutrients, 9(2):164 Nutrients, Vol 9, Iss 2, p 164 (2017) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu9020164 |
| Popis: | This paper aims to compare the metabolic effects of glucose-fructose co-ingestion (GLUFRU) with glucose alone (GLU) in exercising individuals with type 1 diabetes mellitus. Fifteen male individuals with type 1 diabetes (HbA1c 7.0% ± 0.6% (53 ± 7 mmol/mol)) underwent a 90 min iso-energetic continuous cycling session at 50% VO2max while ingesting combined glucose-fructose (GLUFRU) or glucose alone (GLU) to maintain stable glycaemia without insulin adjustment. GLUFRU and GLU were labelled with (13)C-fructose and (13)C-glucose, respectively. Metabolic assessments included measurements of hormones and metabolites, substrate oxidation, and stable isotopes. Exogenous carbohydrate requirements to maintain stable glycaemia were comparable between GLUFRU and GLU (p = 0.46). Fat oxidation was significantly higher (5.2 ± 0.2 vs. 2.6 ± 1.2 mg·kg(-1)·min(-1), p < 0.001) and carbohydrate oxidation lower (18.1 ± 0.8 vs. 24.5 ± 0.8 mg·kg(-1)·min(-1)p < 0.001) in GLUFRU compared to GLU, with decreased muscle glycogen oxidation in GLUFRU (10.2 ± 0.9 vs. 17.5 ± 1.0 mg·kg(-1)·min(-1), p < 0.001). Lactate levels were higher (2.2 ± 0.2 vs. 1.8 ± 0.1 mmol/L, p = 0.012) in GLUFRU, with comparable counter-regulatory hormones between GLUFRU and GLU (p > 0.05 for all). Glucose and insulin levels, and total glucose appearance and disappearance were comparable between interventions. Glucose-fructose co-ingestion may have a beneficial impact on fuel metabolism in exercising individuals with type 1 diabetes without insulin adjustment, by increasing fat oxidation whilst sparing glycogen. |
| Databáze: | OpenAIRE |
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