Plasma lipids and lipoproteins in Japanese male patients with coronary artery disease and in their relatives
| Autor: | Tatsuo Kokubu, Yoichi Imamura, Tadafumi Joh, Mareomi Hamada, Hitoshi Kukita |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Alcohol Drinking Population Coronary Disease Coronary artery disease chemistry.chemical_compound Sex Factors High-density lipoprotein Internal medicine Plasma lipids medicine Humans Family Obesity education Triglycerides education.field_of_study Triglyceride Cholesterol business.industry Smoking Hypertriglyceridemia Middle Aged medicine.disease Endocrinology chemistry Male patient Hypertension Female lipids (amino acids peptides and proteins) Lipoproteins HDL Cardiology and Cardiovascular Medicine business |
| Zdroj: | Atherosclerosis. 42:21-29 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/0021-9150(82)90122-8 |
| Popis: | Plasma cholesterol (CH), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) were measured in 92 consecutive Japanese male subjects undergoing diagnostic coronary cineangiography. Sixty-nine of them were classified as having coronary artery disease (CAD), the remaining 23 subjects were classified as having normal coronary arteries (NCA). The CAD group had significantly lower HDL-C and higher TG levels than the NCA group. However, there was no significant difference in plasma CH between the two groups. First-degree relatives of the CAD patients were also investigated. The male blood relatives of the CAD patients also had significantly lower HDL-C and higher TG levels than the non-blood male relatives and healthy control males. The female blood relatives, however, showed no significant differences from the non-blood female relatives and the healthy control females in plasma CH, TG and HDL-C levels. These results suggest that low HDL-C and hypertriglyceridemia are the prevalent coronary risk factors, rather than hypercholesterolemia, in a population with a low fat intake such as the Japanese, and that these lipid abnormalities are related to sex and genetic factors. |
| Databáze: | OpenAIRE |
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