Inhibition of HIV-1 Tat Activity Correlates with Down-Regulation of bcl-2 and Results in Reduction of Angiogenesis and Oncogenicity
| Autor: | Patrizia Bagnarelli, Catia Piola, Simona Talevi, Laura Possati, Davide Gibellini, Romina Rocchetti, Antonella Caputo, Maria Agnese Menegatti, Giuseppe Barbanti-Brodano, Michela Merlin, M. Fabris, Alfredo Corallini, Riccardo Sampaolesi |
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| Jazyk: | angličtina |
| Předmět: |
Gene Expression Regulation
Viral Cell type Carcinogenicity Tests Angiogenesis Genetic enhancement bel-2 Down-Regulation Mice Nude Mice Transgenic Biology medicine.disease_cause Antibodies Mice angiogenesis oncogenicity Downregulation and upregulation Virology angiogenesis and oncogenicity Tumor Cells Cultured medicine Animals RNA Messenger HIV-1 Tat protein quantitative RT-PCR Mice Inbred BALB C Neovascularization Pathologic Effector Distamycins apoptosis Antisense Elements (Genetics) Proto-Oncogene Proteins c-bcl-2 Apoptosis bcl-2 expression Gene Products tat HIV-1 Cancer research HIV-1 tat bel-2 angiogenesis and oncogenicity tat Gene Products Human Immunodeficiency Virus HIV-1 tat Carcinogenesis Intracellular |
| Zdroj: | Virology. (1):1-7 |
| ISSN: | 0042-6822 |
| DOI: | 10.1006/viro.2002.1459 |
| Popis: | The Tat protein of the human immunodeficiency virus type 1 promotes survival and growth and inhibits apoptosis of different cell types. These effects of Tat are attributed to the induction of bcl-2 gene expression. In this study we show that the blocking of both intracellular and extracellular Tat correlates with a decrease of bcl-2 transcripts, leading in vitro to a lower growth rate and attenuation of the transformed phenotype and in vivo to a reduced angiogenic and oncogenic activity of Tat-expressing cells. These results support the notion that bcl-2 is an effector of Tat-induced angiogenesis and oncogenesis and indicate that the blocking of Tat functions by immunoprophylactic, pharmacological, and gene therapy approaches may help to control oncogenesis during AIDS. |
| Databáze: | OpenAIRE |
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