Predictive factors and impact of full donor T-cell chimerism after reduced intensity conditioning allogeneic stem cell transplantation
| Autor: | Odile Avinens, Jean-François Eliaou, Patrice Viens, Catherine Faucher, Mohamad Mohty, Didier Blaise |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Transplantation Conditioning Myeloid Adolescent T-Lymphocytes CD3 T cell Cell Graft vs Host Disease Transplantation Chimera urologic and male genital diseases Predictive Value of Tests Recurrence hemic and lymphatic diseases Internal medicine medicine Humans Transplantation Homologous neoplasms Aged Myeloproliferative Disorders biology business.industry Siblings Incidence (epidemiology) Hematopoietic Stem Cell Transplantation Hematology Middle Aged Prognosis female genital diseases and pregnancy complications Transplantation Kinetics medicine.anatomical_structure Immunology biology.protein Female Stem cell business |
| Zdroj: | Haematologica. 92:1004-1006 |
| ISSN: | 1592-8721 0390-6078 |
| DOI: | 10.3324/haematol.10971 |
| Popis: | This study investigated the kinetics of CD3+-T cell chimerism (TCC) in 102 patients receiving reduced intensity conditioning allogeneic stem cell transplantation (RIC-allo-SCT) from an HLA-identical sibling. Patients with full donor TCC at day 30 had a higher incidence of grade 2-4 acute GVHD compared to patients in mixed TCC (cumulative-incidence, 61% vs. 35%; p=0.01). The delayed establishment of full donor TCC in myeloid malignancies was associated with a higher incidence of relapse (40% vs. 0; p=0.002), suggesting that monitoring of the kinetics of TCC is mandatory after RIC-allo-SCT. |
| Databáze: | OpenAIRE |
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