Orexin-1 receptor blockade differentially affects spatial and visual discrimination memory facilitation by intracranial self-stimulation
| Autor: | Gemma Huguet, Laura Aldavert-Vera, Soleil García-Brito, Pilar Segura-Torres, Elisabet Kádár |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (Espanya) |
| Rok vydání: | 2019 |
| Předmět: |
Male
Cognitive Neuroscience Morris water navigation task Experimental and Cognitive Psychology 050105 experimental psychology 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine SB-334867 Neurochemical Self Stimulation Spatial Processing Memory Orexin Receptors Cervell -- Malalties -- Tractament Animals 0501 psychology and cognitive sciences Rats Wistar Medial forebrain bundle Maze Learning Spatial Memory 05 social sciences Medial Forebrain Bundle Cervell -- Estimulació Blockade Orexin Brain -- Diseases -- Treatment Brain stimulation Facilitation Visual Perception Implicit memory Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | © Neurobiology of Learning and Memory, 2020, vol. 169, art. núm.107188 Articles publicats (D-B) García-Brito, Soleil Aldavert Vera, Laura Huguet i Blanco, Gemma Kádár García, Elisabeth Segura i Torres, Pilar 2020 Orexin-1 receptor blockade differentially affects spatial and visual discrimination memory facilitation by intracranial self-stimulation Neurobiology of Learning and Memory 169 art. núm.107188 DUGiDocs – Universitat de Girona instname |
| ISSN: | 1095-9564 |
| Popis: | Intracranial self-stimulation (ICSS) of the medial forebrain bundle is an effective treatment to facilitate memory. Performance in both explicit and implicit memory tasks has been improved by ICSS, and this treatment has even been capable of recovering loss of memory function due to lesions or old age. Several neurochemical systems have been studied in regard to their role in ICSS effects on memory, however the possible involvement of the orexinergic system in this facilitation has yet to be explored. The present study aims to examine the relationship between the OX1R and the facilitative effects of ICSS on two different types of memory tasks, both carried out in the Morris Water Maze: spatial and visual discrimination. Results show that the OX1R blockade, by intraventricular administration of SB-334867, partially negates the facilitating effect of ICSS on spatial memory, whereas it hinders ICSS facilitation of the discrimination task. However, ICSS treatment was capable of compensating for the severe detrimental effects of OX1R blockade on both memory paradigms. These results suggest different levels of involvement of the orexinergic system in the facilitation of memory by ICSS, depending on the memory task This research was supported by the Spanish Ministerio de Economía y Competitvidad via I+D projects: PSI2013-41018-P, PSI2017-83202-C2-1-P and PSI2017-83202-C2-2-P and predoctoral grant (BES-2014-068393). |
| Databáze: | OpenAIRE |
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