Giant cell hepatitis and autoimmune hemolytic anemia after chickenpox
| Autor: | Kaan Kavakli, Rasit Vural Yagci, Demir Gokce, Sait Şen, Masallah Baran, Funda Ozgenc, Funda Yilmaz, Omer Berk |
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| Rok vydání: | 2010 |
| Předmět: |
Drug
media_common.quotation_subject Giant cell hepatitis Disease Giant Cells Hepatitis Antibodies Monoclonal Murine-Derived Chickenpox Fatal Outcome Rescue therapy Humans Immunologic Factors Medicine media_common Immunosuppressive treatment business.industry Gastroenterology Infant medicine.disease Immunology Female Rituximab Anemia Hemolytic Autoimmune Autoimmune hemolytic anemia business medicine.drug |
| Zdroj: | The Turkish Journal of Gastroenterology. 21:448-451 |
| ISSN: | 2148-5607 1300-4948 |
| DOI: | 10.4318/tjg.2010.0135 |
| Popis: | Autoimmune hemolytic anemia with giant cell hepatitis is a distinct entity in children. It is usually fatal with progressive liver disease. Immunosuppressive treatment with conventional drugs offers some response; however, it is usually only temporary. Alternative therapeutic options with monoclonals have been reported with promising remission of the disease. We report a case with autoimmune hemolytic anemia+giant cell hepatitis after varicella infection. She was resistant to standard immunosuppressive combinations, and rescue therapy with rituximab was used. Remission was not achieved with the drug and the child died with septic complication. |
| Databáze: | OpenAIRE |
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