Treatment for metastatic nasopharyngeal carcinoma
| Autor: | H. Errihani, Y. Bensouda, M. Jabri, R. Rahhali, N. Ahbeddou, W. Kaikani, H. Boussen, H. Mrabti |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Metastasis Targeted therapy Capecitabine Drug Delivery Systems Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Carcinoma Nasopharyngeal carcinoma Humans Chemotherapy Neoplasm Invasiveness Neoplasm Staging Clinical Trials as Topic business.industry Nasopharyngeal Neoplasms medicine.disease Prognosis Combined Modality Therapy Gemcitabine Radiation therapy Otorhinolaryngology Carcinoma Squamous Cell Metastatic Radiotherapy Adjuvant Surgery Neoplasm Recurrence Local business medicine.drug |
| Zdroj: | European Annals of Otorhinolaryngology, Head and Neck Diseases. (2):79-85 |
| ISSN: | 1879-7296 |
| DOI: | 10.1016/j.anorl.2010.10.003 |
| Popis: | SummaryNasopharyngeal carcinoma (NPC) is a specific entity different from head and neck carcinoma. Incidence is higher in South-East Asia and North Africa. Prognosis, especially for locally advanced stages (IIB - IVB) and metastasis, remains poor: more than third of cases will present local and/or metastatic recurrence. Overall 5-year survival for all NPC stages ranges from 50% to 70%.The role of chemotherapy in metastasis is well established, and remains an important palliative treatment, although no randomized trial has been reported comparing the different chemotherapy regimens. As 1st-line treatment, platin-based regimens seems optimal; in 2nd line and after progression under platins, there is no consensus: monotherapy with drugs such as gemcitabine, capecitabine or taxanes has been the most widely tested, with acceptable results. Future trials should integrate targeted therapy, in the light of overexpression of EGFR1 and C-kit in NPC.The present study presents a review of the literature concerning the various studies of metastatic NPC. |
| Databáze: | OpenAIRE |
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