| Autor: |
N. I. Wedel, Marijke A. M. Von Der Mohlen, B. J. M. Delemarre, Robbert J. de Winter, Sander J. H. van Deventer |
| Rok vydání: |
1995 |
| Předmět: |
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| Zdroj: |
Journal of the American College of Cardiology. 25:76A |
| ISSN: |
0735-1097 |
| DOI: |
10.1016/0735-1097(95)91768-s |
| Popis: |
The protective effect of rBPI23on the circulatory changes induced by experimental endotoxemia in humans was tested in a controlled blinded crossover study. Eight healthy male volunteers were challenged twice with an intravenous bolus injection of endotoxin (40 EU/kg) and concurrently received either rBPI23(1 mg/kg) or placebo. Hemodynamic parameters were obtained non-invasively over a period of twelve hours by means of M-mode-, Twodimensional- and Doppler Echocardiography. Blood Pressure was recorded using a Dynamap. rBPl23significantly reduced endotoxin-induced increase in Heartrate (85 ± 5 versus 67 ± 5 Beat/min, P = 00078). Cardiac Index (3.98 ± 0.25 versus 3.28 ± 0.27 L/min/m2, P = 00156), and Maximal Velocity in the Left Ventricular Outflow Tract (1.26 ± 0.07 versus 1.09 ± 0.05 m/sec,P l 0.05). rBPI23diminished the endotoxin-induced decrease in Systemic Vascular Resistance (1633 ± 79 versus 2051 ± 134 dyne*sec/cm-5, P = 0.0304). rBPI23did not prevent the endotoxin-induced rise in Body Temperature ( + 1.9°C) and Systolic, Diastolic and Mean Arterial Blood Pressure were comparable in the rBPI23- and placebo-treatment arm. Both treatment periods showed a small reduction in End-SystOlic and End-Diastolic Volumes as measured by M-mode. Circulatory changes induced by endotoxin lasted for 12 hours. The protective effect of rBPI23was maximal between 1:30 and 4:00 hours after the start of the endotoxin infusion. Conclusion These results indicate that rBPI23is capable of attenuating the circulatory effects of endotoxin in humans. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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