Polyacrylamide Ferrogels with Magnetite or Strontium Hexaferrite: Next Step in the Development of Soft Biomimetic Matter for Biosensor Applications

Autor: Felix A. Blyakhman, Zahra Lotfollahi, Alexander P. Safronov, Ekaterina A. Mikhnevich, A.I. Medvedev, Aitor Larrañaga Varga, Sergio Fernandez Armas, Galina V. Kurlyandskaya, Tatyana F. Sklyar
Rok vydání: 2018
Předmět:
magnetic nanoparticles
strontium hexaferrite
magnetite
ferrofluids
polyacrylamide gel
ferrogel
tissue engineering
magnetic biosensors
giant magnetoimpedance
Ferrofluid
Materials science
Polyacrylamide
Acrylic Resins
Giant magnetoimpedance
Biosensing Techniques
02 engineering and technology
lcsh:Chemical technology
01 natural sciences
Biochemistry
Article
Analytical Chemistry
Magnetics
chemistry.chemical_compound
Magnetization
Biomimetics
Elastic Modulus
0103 physical sciences
medicine
lcsh:TP1-1185
Particle Size
Electrical and Electronic Engineering
Magnetite Nanoparticles
Instrumentation
Magnetite
010302 applied physics
Hydrogels
Magnetostriction
021001 nanoscience & nanotechnology
Ferrosoferric Oxide
Atomic and Molecular Physics
and Optics
chemistry
Chemical engineering
Strontium
Magnetic nanoparticles
0210 nano-technology
Gels
Xanthan gum
medicine.drug
Zdroj: Addi. Archivo Digital para la Docencia y la Investigación
instname
Sensors; Volume 18; Issue 1; Pages: 257
Sensors, Vol 18, Iss 1, p 257 (2018)
Sensors
Sensors (Basel, Switzerland)
Popis: Magnetic biosensors are an important part of biomedical applications of magnetic materials. As the living tissue is basically a " soft matter." this study addresses the development of ferrogels (FG) with micron sized magnetic particles of magnetite and strontium hexaferrite mimicking the living tissue. The basic composition of the FG comprised the polymeric network of polyacrylamide, synthesized by free radical polymerization of monomeric acrylamide (AAm) in water solution at three levels of concentration (1.1 M, 0.85 M and 0.58 M) to provide the FG with varying elasticity. To improve FG biocompatibility and to prevent the precipitation of the particles, polysaccharide thickeners-guar gum or xanthan gum were used. The content of magnetic particles in FG varied up to 5.2 wt % depending on the FG composition. The mechanical properties of FG and their deformation in a uniform magnetic field were comparatively analyzed. FG filled with strontium hexaferrite particles have larger Young's modulus value than FG filled with magnetite particles, most likely due to the specific features of the adhesion of the network's polymeric subchains on the surface of the particles. FG networks with xanthan are stronger and have higher modulus than the FG with guar. FG based on magnetite, contract in a magnetic field 0.42 T, whereas some FG based on strontium hexaferrite swell. Weak FG with the lowest concentration of AAm shows a much stronger response to a field, as the concentration of AAm governs the Young's modulus of ferrogel. A small magnetic field magnetoimpedance sensor prototype with Co68.6Fe3.9Mo3.0Si12.0B12.5 rapidly quenched amorphous ribbon based element was designed aiming to develop a sensor working with a disposable stripe sensitive element. The proposed protocol allowed measurements of the concentration dependence of magnetic particles in gels using magnetoimpedance responses in the presence of magnetite and strontium hexaferrite ferrogels with xanthan. We have discussed the importance of magnetic history for the detection process and demonstrated the importance of remnant magnetization in the case of the gels with large magnetic particles. This work was supported in part within the framework of the state task of the Ministry of Education and Science of Russia 3.6121.2017/8.9; RFBR grant 16-08-00609 and by the ACTIMAT grant of the Basque Country Government. Selected studies were made at SGIKER Common Services of UPV-EHU and URFU Common Services. We thank I.V. Beketov, A.A. Svalova, Burgoa Beitia, A. Amirabadizadeh, A. Garcia-Arribas and I. Orue for their special support.
Databáze: OpenAIRE
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